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Universities » University of Wisconsin (UW) » M M & I - MEDICAL MICROBIOL & IM.. » 341 - Immunology » Flash Cards

Immunology Final Exam - Flashcards

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Class:M M & I 341 - Immunology
Subject:MEDICAL MICROBIOL & IMMUNOLOGY
University:University of Wisconsin - Madison
Term:Fall 2009
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All of the following are true about organ transplantation EXCEPT? D. Persons who are MHC identical will give a high level of DNA synthesis in a MLR
Which of the following statements about the diagram (neutrophil migration) is NOT true? E. An immunodeficiency disease that involves these events is MHC Class 2 deficiency
Which type of specific immunity would be most effective for protection against intravesicular bacteria? A. T-cell mediated macrophage activation
Which type of specific immunity would be most effective for protection against virus that lands on mucous membrane? D. Neutralization by IgA
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Which type of specific immunity would be most effective for protection against virus replicating within host cell? B. CD8 T-cells (cytotoxic T-cells)
Which type of specific immunity would be most effective for protection against viral particles released into the bloodstream? C. Neutralization by IgG
Which type of specific immunity would be most effective for protection against extracellular pathogens that resist ingestion by E. Opsonization by antibody
Which type of specific immunity would be most effective for protection against intracellular cytosolic pathogens? B. CD8 T-cells (cytotoxic T-cells)
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Which type of specific immunity would be most effective for protection against toxins secreted into bloodstream? C. Neutralization by IgG
Which of the following statements about CD4 and CD8 T-cells is true? C. Both are self-MHC restricted
Which of the following statements about MHC genes/molecules is true? D. MHC Class 2 is present on macrophages, dendritic cells and B cells
Which of the following statements about MHC Class 1 pathway and MHC Class 2 pathway of antigen processing is true? A. MHC Class 1 pathway involves proteasome digestion of peptides into small fragments.
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Which major route of MHC processing and presentation will occur for a live extracellular bacterial pathogen phagocytosed by a ma B. MHC Class 2 pathway
Which major route of MHC processing and presentation will occur for a live virus entering an epithelial cell and replicates? A. MHC Class 1 pathway
Which major route of MHC processing and presentation will occur for an inactivated/dead virus phagocytosed by a macrophage? B. MHC class 2 pathway
Which major route of MHC processing and presentation will occur for a live intracellular bacterial pathogen, phagocytosed by a m B. MHC Class 2 pathway
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The concept illustrated in the figure is: C. Clonal selection and expansion
Section A depicts: C. Development into mature naive lymphocytes
Section B takes place in: C. The secondary lymphoid organs
Which of the following types of cells would be produced in Section C? D. All of the above
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Which process occurs before the event in panel B? B. Allelic exclusion
The concept illustrated in the figure, Section A is: A. Mature naive lymphocytes before infection
Section B takes place in: C. The secondary lymphoid organs
Which of the following statements about an acute inflammatory reaction is true? D. Neutrophils move from blood to tissues at sites of infection.
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Which of the following statements about the events during development of lymphocytes in primary lymphoid organs is true? A. Lack of somatic recombination in VJ and VDJ gene segments results in B-cell deficiency.
Which of the following statements about T-cell activation events is true? B. Mature, naive T cells that recognize [MHC+peptide] in the absence of co-stimulatory molecules become anergic (unresponsive or tolerant)
Which of the following statements about T-cell mediated macrophage activation is true? D. Requires IFN gamma receptor on macrophages.
Which of the following statements about B cells and their responses is true? D. A and B
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Which of the following statements is true about a newborn with SCID? D. A and B
Which of the following is true of the mechanism of the conjugate vaccine for Haemophilus influenzae type b? E. All of the above
A human who has no functional gene for CD40 will be deficient in interactions between: D. A and B
Substances that mediate opsonization are called "opsonins." Which of the following substances can bind to receptors on phagocyti A. C3b
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The symptoms after anti-venom treatment were due to: D. A and B
Soluble antigen:antibody complexes that are not able to be cleared from the bloodstream would be present during which of the fol B. Days 5-6
Toll-like receptor: B. Binding to this induces cytokine secretion by macrophages
Factor B: C. Formation of C3 convertase
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C-reactive protein: D. Acute phase reactant
Adhesion Molecule: A. Upregulation allows tight binding of WBC to vascular endothelium.
Which of the following is NOT true of MHC genes? D. The genes for both class 1 and 2 undergo somatic recombination like Ig genes
Which of the following statements about hypersensitivity reactions is true? B. Type II - cytotoxic hypersensitivity involves antibody directed against antigens on cells of the body. i.e. transfusion reactions, Graves disease.
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Which of the following is true of complement reactions: C. C3b is produced in both alternate and classical pathways
All of the following statements about the primary and secondary antibody response to a given antigen are correct EXCEPT: B. More IgG antibody is produced during the primary response than in the secondary response
Which of the following would represent a normal WBC count? C. 8000 WBC/microliter
If you transferred a preparation of specific human Ig containing only Fab molecules, which of the following Ab functions would N C. Opsonization
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You add the RBCs from a patient to both Anti A and Anti B and determine no agglutination. What is the blood group? D. O
Which of the following statements about secondary lymphoid organs/tissue is true? B. Germinal center formation occurs in all secondary lymphoid organs.
Neutropenia describes the condition of: B. Decreased levels of neutrophils in the blood
For an ELISA that would be used as a screening test to measure ANTIBODIES to HIV, which would be used to coat the wells in step A. HIV
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 All of the following are true about organ transplantation EXCEPT?D. Persons who are MHC identical will give a high level of DNA synthesis in a MLR
 Which of the following statements about the diagram (neutrophil migration) is NOT true?E. An immunodeficiency disease that involves these events is MHC Class 2 deficiency
 Which type of specific immunity would be most effective for protection against intravesicular bacteria?A. T-cell mediated macrophage activation
 Which type of specific immunity would be most effective for protection against virus that lands on mucous membrane?D. Neutralization by IgA
 Which type of specific immunity would be most effective for protection against virus replicating within host cell?B. CD8 T-cells (cytotoxic T-cells)
 Which type of specific immunity would be most effective for protection against viral particles released into the bloodstream?C. Neutralization by IgG
 Which type of specific immunity would be most effective for protection against extracellular pathogens that resist ingestion by E. Opsonization by antibody
 Which type of specific immunity would be most effective for protection against intracellular cytosolic pathogens?B. CD8 T-cells (cytotoxic T-cells)
 Which type of specific immunity would be most effective for protection against toxins secreted into bloodstream?C. Neutralization by IgG
 Which of the following statements about CD4 and CD8 T-cells is true?C. Both are self-MHC restricted
 Which of the following statements about MHC genes/molecules is true?D. MHC Class 2 is present on macrophages, dendritic cells and B cells
 Which of the following statements about MHC Class 1 pathway and MHC Class 2 pathway of antigen processing is true?A. MHC Class 1 pathway involves proteasome digestion of peptides into small fragments.
 Which major route of MHC processing and presentation will occur for a live extracellular bacterial pathogen phagocytosed by a maB. MHC Class 2 pathway
 Which major route of MHC processing and presentation will occur for a live virus entering an epithelial cell and replicates?A. MHC Class 1 pathway
 Which major route of MHC processing and presentation will occur for an inactivated/dead virus phagocytosed by a macrophage?B. MHC class 2 pathway
 Which major route of MHC processing and presentation will occur for a live intracellular bacterial pathogen, phagocytosed by a mB. MHC Class 2 pathway
 The concept illustrated in the figure is:C. Clonal selection and expansion
 Section A depicts:C. Development into mature naive lymphocytes
 Section B takes place in:C. The secondary lymphoid organs
 Which of the following types of cells would be produced in Section C?D. All of the above
 Which process occurs before the event in panel B?B. Allelic exclusion
 The concept illustrated in the figure, Section A is:A. Mature naive lymphocytes before infection
 Section B takes place in:C. The secondary lymphoid organs
 Which of the following statements about an acute inflammatory reaction is true?D. Neutrophils move from blood to tissues at sites of infection.
 Which of the following statements about the events during development of lymphocytes in primary lymphoid organs is true?A. Lack of somatic recombination in VJ and VDJ gene segments results in B-cell deficiency.
 Which of the following statements about T-cell activation events is true?B. Mature, naive T cells that recognize [MHC+peptide] in the absence of co-stimulatory molecules become anergic (unresponsive or tolerant)
 Which of the following statements about T-cell mediated macrophage activation is true?D. Requires IFN gamma receptor on macrophages.
 Which of the following statements about B cells and their responses is true?D. A and B
 Which of the following statements is true about a newborn with SCID?D. A and B
 Which of the following is true of the mechanism of the conjugate vaccine for Haemophilus influenzae type b?E. All of the above
 A human who has no functional gene for CD40 will be deficient in interactions between:D. A and B
 Substances that mediate opsonization are called "opsonins." Which of the following substances can bind to receptors on phagocytiA. C3b
 The symptoms after anti-venom treatment were due to:D. A and B
 Soluble antigen:antibody complexes that are not able to be cleared from the bloodstream would be present during which of the folB. Days 5-6
 Toll-like receptor:B. Binding to this induces cytokine secretion by macrophages
 Factor B:C. Formation of C3 convertase
 C-reactive protein:D. Acute phase reactant
 Adhesion Molecule:A. Upregulation allows tight binding of WBC to vascular endothelium.
 Which of the following is NOT true of MHC genes?D. The genes for both class 1 and 2 undergo somatic recombination like Ig genes
 Which of the following statements about hypersensitivity reactions is true?B. Type II - cytotoxic hypersensitivity involves antibody directed against antigens on cells of the body. i.e. transfusion reactions, Graves disease.
 Which of the following is true of complement reactions:C. C3b is produced in both alternate and classical pathways
 All of the following statements about the primary and secondary antibody response to a given antigen are correct EXCEPT:B. More IgG antibody is produced during the primary response than in the secondary response
 Which of the following would represent a normal WBC count?C. 8000 WBC/microliter
 If you transferred a preparation of specific human Ig containing only Fab molecules, which of the following Ab functions would NC. Opsonization
 You add the RBCs from a patient to both Anti A and Anti B and determine no agglutination. What is the blood group?D. O
 Which of the following statements about secondary lymphoid organs/tissue is true?B. Germinal center formation occurs in all secondary lymphoid organs.
 Neutropenia describes the condition of:B. Decreased levels of neutrophils in the blood
 For an ELISA that would be used as a screening test to measure ANTIBODIES to HIV, which would be used to coat the wells in step A. HIV
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