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Ch.2: Physical & electrical properties of cells in.. - Flashcards

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Class:OTH 4418 - Impact of Neurological Dysfunction on Human Performance
Subject:Occupational Therapy
University:Florida International University
Term:Spring 2011
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astrocytes cells with nutritive & cleanup functions within the CNS
Schwann cells myelin-producing cells in the peripheral nervous system
Neurons cells which recieve and transmit info. via propagation of an electrical signal
Oligodendrocytes Myelin-producing cells in the CNS
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Microglia cells which clean the neural enviornment and contribute to destruction of injured or aging axons
b. dendrite

Which of the following structures of a neuron is specialized for recieving synaptic input from other neurons?

a. cell body

b. dendrite

c. axon

d. axon hillock

e. presynaptic terminal

d. presynaptic terminal

The structural part of a neuron that releases neurotransmitter is the:

a. dendrite

b. axon hillock

c. soma

d. presynaptic terminal

e. postsynaptic terminal

e. have two axon extensions

Pseudounipolar cells:

a. have two dendrites

b. have two somas

c. are not neurons

d. are glial cells

e. have two axon extensions

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c. from peripheral receptors to the CNS

Afferent neurons convey info.:

a. b/t interneurons

b. from the CNS to skeletal muscles

c. from peripheral receptors to the CNS

d. b/t the soma & the presynaptic terminal

e. from the CNS to smooth muscles

Modality-gated channel mechanical force, temperature change, or chemical stimulus
ligand-gated channel neurotransmitter binding to surface of a channel receptor on a postsynaptic membrane
non-gated channel no stimulus required
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voltage-gated channel change in electrical potential across the cell membrane
c. maintained by negatively charged ions inside the membrane, active transport of Na+ and K+, and passive diffusion of Na+, K+, & Cl- through the cell membrane

The resting membrane potential is:

a. the same as the membrane equilibrium potential

b. the voltage difference across a neuron's cell membrane caused by unequal distribution of one specific ion on each side of the membrane

c. maintained by negatively charged ions inside the membrane, active transport of Na+ and K+, and passive diffusion of Na+, K+, &

Cl- through the cell membrane

d. typically measured at 70+ mV as a result of the intracellular enviornment being more positively charged than the extracellular enviornment

e. created by more negative charge inside the membrane than outside because Na+ is continously moved inside the cell membrane by an active transport pump

a. the membrane potential becomes less negative than the resting membrane potential

Depolarization occurs when:

a. the membrane potential becomes less negative than the resting membrane potential

b. the membrane potential becomes more negative than the resting membrane potential

c. the cell is hyperpolarized as a result of an influx of Cl-

d. the presynaptic terminal of a neuron is inhibited by another neuron

e. all membrane channels are closed preventing the influx of Na+

 

e. a,b,c

Local potentials:

a. may be ethier receptor or synaptic potentials

b. spread passively only a short distance along the cell membrane

c. result from stimulation of sensory receptors or from the bingind of neurotransmitter w/ chemical receptor sites on a postsynaptic membrane

e. a, b,c

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c. contain a high density of volatege-gated Na+ channels for rapid depolarization of the membrane

Which of the following is a feature of the nodes of Ranvier?

a. distributed approximately every 1 to 2 mm along the membrane of the cell soma

b. containe a hight density of modality-gated Na+ channels for rapid depolarization of the membrane

c. contain a high density of volatege-gated Na+ channels for rapid depolarization of the membrane

d. have low membrane capacitance preventing the accumulation of electrical charge

e. are heavily myelinated to allow for rapid diffusion of an electrical potential

e. a,b,c

Demyelination of an axon:

a. results in decreased membrane resistance, allowing leakage of electrical current

b. results in slowed propagation of action potentials

c. may prevent propagation of action potentials

d. a,b

e. a,b,c

d. typically affects the schwann cells of larger diameter axons

Peripheral demyelination:

a. typically affects the small diameter axon before the large diameter axons

b. is the cause of multiple sclerosis

c. affects the structure of oligodendrocytes

d. typically affects the schwann cells of larger diameter axons

e. typically affects the axon at the ventral root of the spinal cord

d. a,b

Guillain-Barre syndrome:

a. involves demyelination of peripheral axons

b. results from an autoimmune attach on schwann cells

c. often affects cranial nerves I & II

d. a,b

e, a,b,c

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e. a,b,c

Multiple sclerosis:

a. results from an autoimmune attack on oligodendrocytes

b. involves demyelination of axons within the CNS

c. has signs and symptoms associated with bothe motor and sensory impairment

d. a,b

e, a,b,c

action potential

a large change in the electrical potential of a neuron’s cell membrane, resulting in the rapid spread of an electrical signal along the cell membrane

afferent neuron

(1) neuron that brings information into the central nervous system (2)

neuron that transmits information toward a structure

 

anterograde transport

movement of proteins and neurotransmitters from the soma to

the axon

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astrocytes

macroglia that play a critical role in nutritive and cleanup functions within the central nervous system

axon

a process that extends from the cell body of a neuron. Most axons conduct signals away from the cell body. The only axons that conduct information toward the cell body are the distal axons of primary afferent neurons, which conduct signals to the dorsal root ganglion or cranial nerve ganglion.

convergence

(1) multiple inputs from a variety of different cells terminating on a single

neuron (2) movement that directs the eyes toward the midline

dendrite

process that extends from the cell body of a neuron. Dendrites conduct

information toward the cell body.

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depolarized

the electrical state of a neuron’s cell membrane when the membrane

potential becomes less negative than the resting potential

divergence

the branching of a single neuronal axon to synapse with a multitude of

neurons

efferent neuron

(1) neuron that relays commands from the central nervous system to the

smooth and skeletal muscles and glands of the body (2) neuron that transmits information away from a structure

equilibrium potential

the electrical membrane potential at which any diffusible ion is

electrically and chemically distributed equally on the two sides of the membrane

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glia

the support cells of the nervous system, including oligodendrocytes, Schwann cells, astrocytes, and microglia

Guillain-Barre Syndrome

acute, autoimmune peripheral polyneuropathy characterized

by progressive paralysis, burning and/or tingling sensations, and pain

hyperpolarized

the electrical state of a neuron’s cell membrane when the membrane

potential becomes more negative than its resting potentia

interneurons

neurons that either process information locally or convey information short

distances from one site in the nervous system to another

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ligand-gated channels

neuronal membrane ion channels that open in response to the

binding of a chemical neurotransmitter

local potential

a small change in the electrical potential of a neuron’s cell membrane that

is graded in both amplitude and duration

macroglia

the large support cells of the nervous system, including oligodendrocytes,

Schwann cells, and astrocytes

modality-gated channels

membrane ion channels, specific to sensory neurons, that open

in response to mechanical forces (i.e., stretch, touch, pressure) or thermal or chemical

changes

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microglia

the small support cells of the nervous system

modulation

long-lasting changes in the electrical potential of a neuron’s cell membrane

that alters the flow of ions across the cell membrane

multiple sclerosis

a disease characterized by random, multifocal demyelination limited

to the central nervous system. Signs and symptoms include numbness, paresthesias, Lhermitte’s sign, asymmetrical weakness, and/or ataxia.

multipolar cells

neurons having multiple dendrites arising from many regions of the cell

body and possessing a single axon

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myelin

the sheath of proteins and fats formed by oligodendrocytes and Schwann cells to envelop the axons of nerve cells. Provide physical support and insulation for conduction of electrical signals by neurons.

neurons

the electrically excitable nerve cell of the nervous system

nodes of Ranvier

interruptions in the myelin sheath that leave small patches of axon

unmyelinated. These unmyelinated patches contain a high density of voltage-gated Na+

channels that contribute to the generation of action potentials.

oligodendrocytes

macroglia that form myelin sheaths, enveloping several axons from

several neurons. Found within the central nervous system

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presynaptic terminal

the end projection of an axon, specialized for releasing

neurotransmitter into the synaptic cleft

pseudounipolar cells

neurons that have one projection from the cell body that later

divides into two axonal roots. A pseudounipolar cell has no true dendrites.

refractory period

the time period during an action potential when no stimulus, no matter

how strong, will elicit another action potential

resting membrane potential

the difference in electrical potential across the cell

membrane of a neuron when the neuron is neither receiving nor transmitting

information (i.e., the electrical state of a neuron’s cell membrane when the cell is at

rest [neither electrically excited nor inhibited])

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retrograde transport

movement of some substances from the axon back to the soma for

recycling

saltatory conduction

rapid propagation of an action potential by jumping from one node

of Ranvier to the next along a myelinated axon

Schwann cells

macroglia that form myelin sheaths enveloping only a single neuron’s

axon or partially surrounding several axons. Found in the peripheral nervous system.

soma

cell body, the metabolic center of a cell

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spatial summation

the cumulative effect of receptor or synaptic potentials occurring

simultaneously in different regions of the neuron

synaptic potential

local potentials generated at a postsynaptic membrane

temporary summation

the cumulative effect of a series of either receptor potentials or

synaptic potentials that occur within milliseconds of each other

voltage-gated channels

membrane ion channels that open in response to changes in

electrical potential across a neuron’s cell membrane

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threshold level the sufficient level of depolarization for generation of an action potential
synaptic cleft the space b/t neurons  & serves as the site for interneuronal communication
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List View: Terms & Definitions

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 astrocytescells with nutritive & cleanup functions within the CNS
 Schwann cellsmyelin-producing cells in the peripheral nervous system
 Neuronscells which recieve and transmit info. via propagation of an electrical signal
 OligodendrocytesMyelin-producing cells in the CNS
 Microgliacells which clean the neural enviornment and contribute to destruction of injured or aging axons
 b. dendrite

Which of the following structures of a neuron is specialized for recieving synaptic input from other neurons?

a. cell body

b. dendrite

c. axon

d. axon hillock

e. presynaptic terminal

 d. presynaptic terminal

The structural part of a neuron that releases neurotransmitter is the:

a. dendrite

b. axon hillock

c. soma

d. presynaptic terminal

e. postsynaptic terminal

 e. have two axon extensions

Pseudounipolar cells:

a. have two dendrites

b. have two somas

c. are not neurons

d. are glial cells

e. have two axon extensions

 c. from peripheral receptors to the CNS

Afferent neurons convey info.:

a. b/t interneurons

b. from the CNS to skeletal muscles

c. from peripheral receptors to the CNS

d. b/t the soma & the presynaptic terminal

e. from the CNS to smooth muscles

 Modality-gated channelmechanical force, temperature change, or chemical stimulus
 ligand-gated channelneurotransmitter binding to surface of a channel receptor on a postsynaptic membrane
 non-gated channelno stimulus required
 voltage-gated channelchange in electrical potential across the cell membrane
 c. maintained by negatively charged ions inside the membrane, active transport of Na+ and K+, and passive diffusion of Na+, K+, & Cl- through the cell membrane

The resting membrane potential is:

a. the same as the membrane equilibrium potential

b. the voltage difference across a neuron's cell membrane caused by unequal distribution of one specific ion on each side of the membrane

c. maintained by negatively charged ions inside the membrane, active transport of Na+ and K+, and passive diffusion of Na+, K+, &

Cl- through the cell membrane

d. typically measured at 70+ mV as a result of the intracellular enviornment being more positively charged than the extracellular enviornment

e. created by more negative charge inside the membrane than outside because Na+ is continously moved inside the cell membrane by an active transport pump

 a. the membrane potential becomes less negative than the resting membrane potential

Depolarization occurs when:

a. the membrane potential becomes less negative than the resting membrane potential

b. the membrane potential becomes more negative than the resting membrane potential

c. the cell is hyperpolarized as a result of an influx of Cl-

d. the presynaptic terminal of a neuron is inhibited by another neuron

e. all membrane channels are closed preventing the influx of Na+

 

 e. a,b,c

Local potentials:

a. may be ethier receptor or synaptic potentials

b. spread passively only a short distance along the cell membrane

c. result from stimulation of sensory receptors or from the bingind of neurotransmitter w/ chemical receptor sites on a postsynaptic membrane

e. a, b,c

 c. contain a high density of volatege-gated Na+ channels for rapid depolarization of the membrane

Which of the following is a feature of the nodes of Ranvier?

a. distributed approximately every 1 to 2 mm along the membrane of the cell soma

b. containe a hight density of modality-gated Na+ channels for rapid depolarization of the membrane

c. contain a high density of volatege-gated Na+ channels for rapid depolarization of the membrane

d. have low membrane capacitance preventing the accumulation of electrical charge

e. are heavily myelinated to allow for rapid diffusion of an electrical potential

 e. a,b,c

Demyelination of an axon:

a. results in decreased membrane resistance, allowing leakage of electrical current

b. results in slowed propagation of action potentials

c. may prevent propagation of action potentials

d. a,b

e. a,b,c

 d. typically affects the schwann cells of larger diameter axons

Peripheral demyelination:

a. typically affects the small diameter axon before the large diameter axons

b. is the cause of multiple sclerosis

c. affects the structure of oligodendrocytes

d. typically affects the schwann cells of larger diameter axons

e. typically affects the axon at the ventral root of the spinal cord

 d. a,b

Guillain-Barre syndrome:

a. involves demyelination of peripheral axons

b. results from an autoimmune attach on schwann cells

c. often affects cranial nerves I & II

d. a,b

e, a,b,c

 e. a,b,c

Multiple sclerosis:

a. results from an autoimmune attack on oligodendrocytes

b. involves demyelination of axons within the CNS

c. has signs and symptoms associated with bothe motor and sensory impairment

d. a,b

e, a,b,c

 action potential

a large change in the electrical potential of a neuron’s cell membrane, resulting in the rapid spread of an electrical signal along the cell membrane

 afferent neuron

(1) neuron that brings information into the central nervous system (2)

neuron that transmits information toward a structure

 

 anterograde transport

movement of proteins and neurotransmitters from the soma to

the axon

 astrocytes

macroglia that play a critical role in nutritive and cleanup functions within the central nervous system

 axon

a process that extends from the cell body of a neuron. Most axons conduct signals away from the cell body. The only axons that conduct information toward the cell body are the distal axons of primary afferent neurons, which conduct signals to the dorsal root ganglion or cranial nerve ganglion.

 convergence

(1) multiple inputs from a variety of different cells terminating on a single

neuron (2) movement that directs the eyes toward the midline

 dendrite

process that extends from the cell body of a neuron. Dendrites conduct

information toward the cell body.

 depolarized

the electrical state of a neuron’s cell membrane when the membrane

potential becomes less negative than the resting potential

 divergence

the branching of a single neuronal axon to synapse with a multitude of

neurons

 efferent neuron

(1) neuron that relays commands from the central nervous system to the

smooth and skeletal muscles and glands of the body (2) neuron that transmits information away from a structure

 equilibrium potential

the electrical membrane potential at which any diffusible ion is

electrically and chemically distributed equally on the two sides of the membrane

 glia

the support cells of the nervous system, including oligodendrocytes, Schwann cells, astrocytes, and microglia

 Guillain-Barre Syndrome

acute, autoimmune peripheral polyneuropathy characterized

by progressive paralysis, burning and/or tingling sensations, and pain

 hyperpolarized

the electrical state of a neuron’s cell membrane when the membrane

potential becomes more negative than its resting potentia

 interneurons

neurons that either process information locally or convey information short

distances from one site in the nervous system to another

 ligand-gated channels

neuronal membrane ion channels that open in response to the

binding of a chemical neurotransmitter

 local potential

a small change in the electrical potential of a neuron’s cell membrane that

is graded in both amplitude and duration

 macroglia

the large support cells of the nervous system, including oligodendrocytes,

Schwann cells, and astrocytes

 modality-gated channels

membrane ion channels, specific to sensory neurons, that open

in response to mechanical forces (i.e., stretch, touch, pressure) or thermal or chemical

changes

 microglia

the small support cells of the nervous system

 modulation

long-lasting changes in the electrical potential of a neuron’s cell membrane

that alters the flow of ions across the cell membrane

 multiple sclerosis

a disease characterized by random, multifocal demyelination limited

to the central nervous system. Signs and symptoms include numbness, paresthesias, Lhermitte’s sign, asymmetrical weakness, and/or ataxia.

 multipolar cells

neurons having multiple dendrites arising from many regions of the cell

body and possessing a single axon

 myelin

the sheath of proteins and fats formed by oligodendrocytes and Schwann cells to envelop the axons of nerve cells. Provide physical support and insulation for conduction of electrical signals by neurons.

 neurons

the electrically excitable nerve cell of the nervous system

 nodes of Ranvier

interruptions in the myelin sheath that leave small patches of axon

unmyelinated. These unmyelinated patches contain a high density of voltage-gated Na+

channels that contribute to the generation of action potentials.

 oligodendrocytes

macroglia that form myelin sheaths, enveloping several axons from

several neurons. Found within the central nervous system

 presynaptic terminal

the end projection of an axon, specialized for releasing

neurotransmitter into the synaptic cleft

 pseudounipolar cells

neurons that have one projection from the cell body that later

divides into two axonal roots. A pseudounipolar cell has no true dendrites.

 refractory period

the time period during an action potential when no stimulus, no matter

how strong, will elicit another action potential

 resting membrane potential

the difference in electrical potential across the cell

membrane of a neuron when the neuron is neither receiving nor transmitting

information (i.e., the electrical state of a neuron’s cell membrane when the cell is at

rest [neither electrically excited nor inhibited])

 retrograde transport

movement of some substances from the axon back to the soma for

recycling

 saltatory conduction

rapid propagation of an action potential by jumping from one node

of Ranvier to the next along a myelinated axon

 Schwann cells

macroglia that form myelin sheaths enveloping only a single neuron’s

axon or partially surrounding several axons. Found in the peripheral nervous system.

 soma

cell body, the metabolic center of a cell

 spatial summation

the cumulative effect of receptor or synaptic potentials occurring

simultaneously in different regions of the neuron

 synaptic potential

local potentials generated at a postsynaptic membrane

 temporary summation

the cumulative effect of a series of either receptor potentials or

synaptic potentials that occur within milliseconds of each other

 voltage-gated channels

membrane ion channels that open in response to changes in

electrical potential across a neuron’s cell membrane

 threshold levelthe sufficient level of depolarization for generation of an action potential
 synaptic cleftthe space b/t neurons  & serves as the site for interneuronal communication