Koofers

Final Study Guide - Flashcards

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Class:ZOO 250 - ANATOMY AND PHYSIOLOGY LECTURE I
Subject:Zoology
University:Southeastern Louisiana University
Term:Spring 2011
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Anatomy Study of form
examining the structure of the human body
  • inspection
  • palpation
  • auscultation
  • percussion
Physiology study of function

Hippocrates
  • god's
  • urged to find natural causes of disease
  • father of medicine
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Aristotle
  • Maybe some natural and supernatural causes
Galen
  • most influential text book of the ancient era
  • learned through animal dissection
Avicenna Meimonides
  • muslims
  • wrote very influential books
Versallus
  • first to do a "dissection" with his class
  • dissected human body
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Hooke
  • Microscope
  • simple microscope to look at dead cells
Leeuwenhook
  • looked at living cells viewed under microscope
Schwann/Schledin
  • cell theory
Charles Darwin
  • Evolutions
  • theory of Natural Selection
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evolutions
  • individuals do not evolve only populations
theory of natural selection
  • how those species originate throughout time
Vestigal Organs
  • Remnants of organs that were better developed and more functional in ancestors
Arboreal adaptations
  • treetop
  • mobil shouldeers
  • opposable thumbs made hands prehensile
  • forward-facing eyes-depth preception
  • color-vision
  • larger-brains and good memory
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Bipedalism
  • Skeletal and muscular modifications
  • increased brain volume
  • family life & social changes
Atom-molecule-macromolecule-organelle-cell-tissue-organ-organsystem-organism Hierarchy of complexity
chemical elements (95% of body weight) oxygen, carbon, hydrogen, nitrogen, calcium & phosphorous
Minerals (4% body weight) Calcium, Phosphorous, Chlorine, Mg, K, Na, I Fe, Zn, Cu & S
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Electrolytes needed for nerve & muscles functions are mineral salts
Radioactity Isotopes
Isotopes
  • Varieties of an element, same chemical behavior differ in physical behavior
  • breakdown produces dangerous free radicals
molecules 2 or more atoms united by a chemical bond
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Chemical Reaction
  • a process in which a chemical bond is formed or broke
  • Decomposition
  • synthesis

Decomposition Reactions
  • Large to small 
  • ab > A+B
synthesis Small to big
a + b  > ab
Metabolism All the chemical reactions of the body

  • catabolism
  • anabolism
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Catabolism Energy releasing (exergonic) decomposition reactions
Anabolism Energy storing (endergonic) synthesis reactions

  • requires energy input
  • production of protein or fat
Organic Macromolecules Carbohydrates
lipids
protein
nucleic acid
Squamous Cells thin, flat , and often have a bulge where the nucleus is much like the shape of a fried egg
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Polygonal cells irregularly angular shaped with four, five, or more sides
Stellate cell nerve cells that have multiple extensions that give them a starlike shape
Cuboidal Cells  squarish and approximately as tall as they are wide
Columnar Cells line the intestines and are markedly taller than wide

liver cells are good example
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Spheroid egg cells and fat cells 

round to ovale
Fibrous Skeletal muscle cells
  • threadlike shape
10 - 15 micrometers in diameter human cell size
100 micrometer in diameter egg cells
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1 meter long nerve cells
Major constituents of cell
  • Plasma (cell) membrane
  • Organelles
  • cytoskeleton
  • cytosol
  • extracellular fluid
Plasma Membrane made of proteins and lipids
Cytosol intercellular fluid
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Diffusion
  • movement of particles from area of high concentration to area of low concentration

  • aka movement down the concentration gradient
temp, molecular weight, steepness of gradient, membrane surface area, membrane permeability factors that affect the diffusion rate
Temperature increase temp increase the motion
molecular weight larger molecules move slower
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steepness of gradient increase the difference and increase the rate
membrane surface area increase the area increase the rate
membrane permeability increase the permeability and increase the rate
osmosis flow of water from side w/ higher water concentration to the side with lower water concentration across a selectively permeable membrane
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hypotonic environment environment has less concentration of solute

cell swells and may burst  (lyse)
hypertonic environment environment has more concentration of solute

cell may shrink and shrivel  (crenate)
Isotonic solution everything equals inside and outside environments

no change in shape nor size
Active transport carrier-mediated trasport of solute through a membrane up (against) its concentration gradient

ATP energy is consumed

examples:  sodium potassium pump keeps K+ concentration higher inside the cell
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sodium potassium pump (ICF, ECF)  consumes one ATP and exchanges three Na+ for 2 K+

K+ is higher in 
Na+ is higher in
Vescular Transport processes that move particles through the membrane in vesicles
Endocytosis vesicular processes that bring material into the cell

phagoyctosis
pinocytosis
receptor
Phagoctosis cell eating (white blood cells)

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Pinocytosis cell drinking 
Receptor mediated endocytosis----particle bind to specific receptor on plasma membrane
Exocytosis discharging material from the cell

example:  discharge of insulin
receptor mediated endocytosis
  • extracellular molecules bind to receptors on plasma membrane; receptors cluster together
  • plasma membrane sinks inward, forms clathrin-coated pit
  • pit separates from plasma membrane, form clathrin-coated vesicle containing concentrated molecules form ECF
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Neutrophil Phagocytosis 5 different types white blood cells 
Integuma system protection

skin, hair, naile
Skeletal System structure, support
muscular system movement
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lymphatic system lymph nodes, tonsils, speed, thymus

lympthatic organs are dominated by WBCs
Respiratory System Cellular respiration
urinary system removing wastes/ regulates blood pressure
nervous system sensory & internal communication
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endocrine system hormones
circulatory system blood flow, distribution of nutrients 

heart and blood vessels

blue blood until it reaches the lungs ; further from heart darker blood
Digestive system nutrients breakdown and absorption 

metabolism and disposal and cleansing of blood

reproductive system dont need this to live
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anatomical position standard frame of reference for anatomical descriptions & dissections

palms are supinated (face foward)
Sagittal Plane right and left regions
median (midsagittal) plane
Frontal Plane anterior (front) and Posterior (back) portions
transverse Plane superior (upper) and inferior (lower) portions

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ventral/ dorsal going toward front/back
superior/inferior above/below
proximal/distal close to pt attachment/ far
medial/lateral toward inside/ outside
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superficial/deep close to surface/ far
homeostasis body's ability to detect change and activate mechanisms that oppose it.
negative feedback keeps variable close to the set point


example thermoregulation
positive feedback leads to greater change in the same directions


example:  child birth
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Epithelium Tissue
  • flat sheet of closely adhering cells on or more cells thick
  • no room for blood vessels
  • lines body cavities and organs
  • constitues most glands
  • basement membrane anchors epithelium to connective tissue
simple epithelia all cells touch basement membrane

can be:
simple squamous
simple cuboidal
simple columnar
pseudostratified
stratified epithelia not all cell touch basement membrane; multiple layers
2 to 20 or more layers of cells

can be:
stratified squamous
stratified cuboidal
stratified columnar
transitional epithelium
simple squamous
  • type of epithelial tissue
  • flat
  • rapid diffusion or transport of substances
  • secretes serous fluid
  • found in (lungs, kidneys, blood vessels, and lining of body cavities)
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simple cuboidal
  • type of epithelial tissue
  • cube
  • absorption and secretions
  • mucus production and movement
  • liver, thyroid, mammary, and salivary glands, bronchioles, and kidney tubules
simple columnar
  • type of epithelial tissue
  • very long and column
  • absorption and secretion; movement
  • lining the GI tract, uterus, kidney, and uterine tubes
  • found in goblet cells
Psudostratified
  • secretes and propels mucus
  • respiratory tract and portions of male urethra
goblet cells mucus secreting cells
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stratified squamous keratinized and non karatinized
keratinized
  • epidermis; palms and soles heavily keratinized
  • resists abrasion; retards water loss through skin; resists penetration by pathogenic organisms
nonkeratinized
  • tongue, oral mucosa, esophagus, and vagina
  • resist abrasion and penetration of pathogens
stratified cuboidal
  • secretes sweat; sperm production and produces ovarian hormones
  • sweat gland ducts; ovarian follicles and seminiferous tubules
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transitional epithelium change from round to flat when stretched

example:  ureter and bladder
connective tissue
  • most cells are not in direct contact with each other
  • highly vascular
  • functions 
  1. binding of organs, support and movement, physical and immune protections, storage, heath production, transport
  • more matrix than cells
four types:  fibrous, loose, dense, supportive

fibrous CT cells (fibroblast, macrophages, leukocytes, plasma cells, mast cells, adipocytes)

fibers (collagenous, reticular, elastic)
Macrophages fibrous cells able to phagocytise
 

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Leukocytes fibrous white blood cells

immune protection

Plasma Cells fibrous CT cell that secretes antibodies
Mast Cell fibrous CT cell secret heparin and histamine
heparin blood doesnt clot
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histamine widen blood vessels
adipocytes fibrous ct  fat cells

store lipids
collagenous fibers cant stretch

reticular fibers coated with glycoprotein
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elastic fibers very stretchable
Loose CT Areolar tissue
reticular tissue
adipose tissue

areolar tissue all cell types present, mostly collagenus fibers

underlies all epithelia, in serous membrane, between muscles, passageways for nerves and blood vessels
reticular tissue mesh of reticular fibers and fibroblasts

found in lymph nodes, spleen, thymus, and bone marrow
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adipose tissue energy storage, insulation, cushioning

areolar tissue, reticular tissue, and blood capillaries between cells
Dense CT Dense regular and Dense irregular
Dense regular all fibers running parallel

tendons and ligaments

tendons muscle to bone

most important to stabilizing joing
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ligaments bone to bone
dense irregular deeper layer of skin; capsules around organs
supportive CT cartilage
  • hyaline cartilage
  • elastic cartilage
  • fibrocartilage
hyaline cartilage
  • fine collagen fibers
  • articular cartilage, costal cartilage, trachea, larynx, fetal skeleton
  • eases joint movement, holds airway open, moves vocal cords during speech
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elastic cartilage
  • elastic fibers
  • provides flexible, elastic support
  • external ear and epiglottis
Fibrocartilage
  • large collagen fibers
  • resists compression and absorbs shock
  • pubic symphysis, menisci, and intervertebral discs
fluid CT blood 

blood plasma
forms :  erythrocytes, leukocyte, and platelets
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erythrocytes
  • red blood cell
  • carry oxygen
leukocytes
  • white blood cells
  • immunity
Platelets
  • blood clotting (help clot) when bleeding needs to be stopped
muscular and nervous excitable tissues
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nervous tissue
  • specialized for communication by electrical and chemical signals
  • neuron parts:  neurosoma, dendrite, axon
neurosoma cell body
dendrites
  • receive signals
  • transmits to neurosoma
axon nerve fiber
  • sends outgoing signals 
  • one of the longest cells
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muscular tissue
  • elongated cells specialized to contract
  • creates movement involved in body and limb movement, digestion, waste, elimination, breathing, speech, and blood circulation
  • produces movement witha  good source of heat
three types
  • skeletal, cardiac, smooth
skeletal muscle
  • most attach to bone
  • have striation
  • voluntary
cardiac muscle
  • mysocytes/cardiocytes-shorter, branched , and notched at ends
  • on centrally located nucleus
  • intercalated discs
  • striated and involuntary
smooth muscles
  • lacks striations and is involuntary
  • visceral muscle
  • propels contents through an organ regulates diameter of blood vessels
  • reacts to hormones

example:  labor
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endocrine Glands lose contact with surface

  • secrete (hormones) directly into blood
  • thyroid, adrenal and pituitary glands
exocrine glands maintain contact with body surface by way of a duct

type: 
  • serous
  • mucous
  • mixed
  • cytogenic
serous glands produce thin, watery secretions

type of exocrine gland

mucous glands found on tongue and roof of mouth

type of exocrine glands
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mixed glands both serous and mucous glands

cytogenic glands release whole cells

sperm and egg cells
methods of secretion merocrine glands

apocrine glands

holocrine glands
merocrine glands vesicles release secretion by exocytosis
  • tear glands, pancreas, gastric glands, and others

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apocrine glands merocrine mode of secretion
  • axillary sweat glands, mammary glands
holocrine gland cells accumulate a product and the entire cell disintegrates
  • oil glands of scalp and glands of eyelids
epidermis karatinized stratified squamous

5 layers:  stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, stratum basale

  • lacks blood vessels
  • diffusion of nutrients
  • nerve endings
  • cells
  • karatinocytes----keratin
stratum corneum
  • 30 layers
  • resistant to abrasion, penetration, and water loss

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stratum lucidum
  • only in thick skin
  • contains eleidin
  • no nucleus or other organelles
stratum granulosum 3-5 layers thick

keratohyalin granule
  • filaggrin
  • epidermal water barrier
stratum spinosum thickest in most skin

produces keratin filaments

8-10 cells thick
stratum basale one cell layer thick

stem cells divide keratinocytes

melanocytes----melanin

tactile (merkel) cells----touch receptor cells
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dermis
  • Loose CT
  • collagen with elastic fiber, reticular fibers, and fibroblasts
  • blood vessels, sweat glands sebaceous glands and nerve endings hair follicles and nail root
  • piloerector muscles
  • dermal papillae-frictions ridges

malignant melanoma
  • arises from melanocytes
  • not common by most deadly 
  • metastasizes rapidly
  • life expectancy----6 months
  • spreads quicker than most
basal cell carcinoma most common

arises from cells in stratum basal
squamous cell carcinoma
  • arises from keratinocytes from stratum spinosum
  • can spread to lymph nodes and become very dangerous
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papillary layer
  • layer of dermis
  • areolar tissue
  • mobility of leukocytes (white blood cells)
  • protect you from anything coming through the dermis
  • most blood vessels supplying
reticular layer
  • dense, irregular CT
  • stretch marks
hypodermis
  • mostly areolar and adipose
  • binds skin to tissues
  • drugs introduced by injection
  • 8% thicker in women than men
cyanosis deficiency of oxygen in blood

cold weather, airway abstruction
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erythema dilated cutaneous vessels


hot weather, exercise, anger
pallor little blood flow through the skin


low blood pressure, anemic, circulatory shock
albinism genetic lack of melanin
jaundice excess of bilirubin in blood


yellowing of skin, eye
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hematoma mass of clotted blood


bruise, hicky

flat curly hair shape
round straight hair shape

red hair more phamelanin than eumalanin
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black hair high concentration of eumalanin
blonde hair very little eumalanin more phamelanin
grey absence of melanin

cortex become hollowed out
debridement removal of eschar
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1st degree burn havent gone through the skin
2nd degree burn gone throught the dermis
3rd degree burn need skin graphs

burn through the dermis and epidermis down to bone
functions of the skin
  • resistance to trauma and infection
  • other barrier functions
  • Vitamin D synthesis
  • sensation
  • thermoregulation
  • nonverbal communication
  • transdermal absorption
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resistance to trauma and infection keratin

acid mantle
other barrier functions waterproofing
UV radiation
harmful chemicals
Vitamin D synthesis skin first step

liver and kidneys complete process
sensation skin is our most extensive sense organ
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thermoregulation thermoreceptors

vasoconstriction/ vasodilation
nonverbal communication acne, birthmark, or scar
Transdermal absorption administration of certain drugs steadily through this skin----adhesive patches
Long, short, flat, irregular
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Long bone rigid levers acted upon by muscle (femur and ulna)
structure:
  • Periosteum & endosteum
  • nutrient foramina
  • Epiphyses & diaphysis
  • compact & spongy
  • marrow cavity
  • articular cartilage
periosteum outer layer of long bone
endosteum inner layer of long bone

cells that can deposit or breakdown
nutrient foramina blood vessels are allowed to penetrate the bones
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epiphyses large end of long bone
diaphysis shaft of  long bone
epiphysial line seperates piphyses from diaphysis 

in adults
compact surface of all bones
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spongy in the ends of long bones
marrow cavity in the middle and contains the marrow
short bones
glide across one another in multiple directions

carpals and tarsals
flat bones protect soft organs

scapula, sternum, cranial, ribs
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irregular bones skull bones

vertebrate, sphenoid, ethnoid
bone marrow red----- myeloid tissue
(child)

yellow----(adults)
four principle types of bone cells osteogenic cell
osteoblasts
osteocytes
osteoclast
osteogenic cell give rise to osteoblast

stem cell
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osteoblast buil

start producing matrix to form bone

becomes trapped in matrix and becomes osteocytes
osteocytes mature bone cell
osteoclast catastrophe

same stem cell as blood

develops from stem cells from a different origin

surface of bone

bone dissolving cells
compact bone
  • lacunae
  • canaliculi
  • central canal
  • osteon
  • interstitial lamella
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spongy bone
  • very few osteon
  • made up or trabeculae
  • needs strength but not a lot of weight
  • develops along the lines of stress
osteogenesis in the human fetus and infant, bone develops by two methods:

intramembranous ossification
endochondral ossification

interstitial growth part of bone growth

bones increase in length
appositional growth the deposition of new bone at the surface
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bone remodeling occurs throughout life 10% per year
Achondroplastic dwarfism failure of cartilage growth in metaphysis
pituitary dwarfism lack of growth hormone
calcium homeostasis is regulated by three hormones: calcitriol, calcitonin, and parathyroid hormone
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hypocalcemia blood calcium deficiency

Na enters cells to easily and excites
muscle spasms, tenisis
hypercalcemia blood calcium excess

Na channels less responsive, nerve and muscular tissue
depress and slugish 

very rare
calcitriol
  • form of vitamin D through the skin, liver, and kidney
  • hormone that stars with the skin from the sunlight
  • kidney then converts vitamin to this
  • its releades to raise the concentration of calcium

  • makes bone resorptions
  • reduce excretion of ca
  • make stomach and intestine absorb more calcium
calcitonin decreases blood calcium back to normal
produced by the thyroid gland
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parathyroid hormone secretion correction for hypocalcemia
  • increased osteoclast
  • reduced osteoblast
  • more urinary phosphate excretion
  • less urinary calcium excretion
stress fracture abnormal trauma to a bone
pathological fracture weakend by disease
nondisplaced cracked but bones still aligned
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displaced bones are not aligned completely broken
comminuted bones broken in 3 or more places

greenstick incomplete fractured causing stress on another bone
closed treatment no surgery 
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opened treatment plates screws to fix
boney joints
  • immovable joint
  • gap between bones ossify
  • fibrous or cartilaginous joint
fibrous joints adjacent bones are bounded by collagen fibers
three kind:
  • sutures
  • gomphoses
  • syndesmosis
sutures
  • immovable
  • bind bones in skull
  • serrate, lap and plane suture
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serrate suture interlocking wavy lines,

coronoid, sagittal, squamous, lamnoid
lap suture miter joint

temporal and squamous

plane suture butt joint

palatine bone
gomphoses attaches tooth to socket
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syndesmoses bound by longer collagen fibers

most movable (between radius and ulna)

least movable (tibia to fibula)
Cartilaginous joints two bones linked by cartilage

synchondroses and symphysis

first ribs attached
synchondroses hyaline cartilage
symphysis fibrocartilage

between the vertebrate
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synovial joints
  • two bones separated by joint cavity filled with synovial fluid
  • joint capsule
  • accessory structures
  • ball and socket, condyler, saddle, plane, hindge, pivet
bursa-synovial fluid filled sac between adjacent muscle and help cushion muscle
tendon sheath cylindrical covers tendon
ball and socket head in a cop

hip and shoulder (only one)

multiaxial
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condylar one bone has a compact surface fits into a compression on the other side

radial and carpals, phalanges and metacarpals

bioxial joint
saddle joint both bones have depression that fit each other
  • trapizia metacarpas
  • sternum and clavical

bioxial
plane joints gliding joints
both have a flat surface
  • carpals and tarsals
  • articulation processes of vertebrate 

bioxial

hidge joints one bone has a compact surface and fits into a depresion

  • knee, elbow, and fingers and toes

monoxial
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pivet joint radius and ulna

occipital

monoxial
zero position position of a joint when in standard anatomical position
flexion decreses joint angle
extension return joint to zero
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hyperextensions increase joint angle beyond zero position
abduction movement away from midline of body
adduction movement towards midline of body
elevation movement that raises the body vertically
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depression lowers the body vertically
protraction anterior movement of body
retraction posterior movement of body
circumduction one end stays stationary and other makes a circular motion
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shoulder
  • glenohumeral joint
  • biceps brachii and rotator cuff
  • five ligaments:  coracohumeral, transverse humeral, glenohumeral
elbow
  • hinge joint
  • radial collateral ligament
  • ulnar collateral ligament
  • radioulnar joint
hip coxal joint
  • deeper sockets
knee joint tibofemoral joint-----hidge joint

patellorfemoral joint------gliding
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orbicularis oculi o---eyelids

i---eyelids
orbicularis oris o & i----lip
sternocleidomastoid flex neck

o----clavicle

i-----mastoid process
proteins that make up skeletal muscle
  • contractile, regulatory, accessory, myofilaments
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contractile myosin and actin
regulatory proteins tropomyosin and troponin
accessory proteins dystrophin
thick myofilament myosin molecule
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elastic myofilament titin-  anchors thick to z disc
tropomyosin
blocks active sites
troponin calcium-binding protein
denervation atrophy shrinkage of paralyzed muscle
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somatic motor neurons each fiber only has one neuron but one neuron can be connected to many fibers
motor unit one nerve fiber and all the muscle fibers innervated
muscle fibers of one motor unit
  • contract in unison
  • weak contraction over wide area
  • ability to sustain long-term contraction
average motor unit 200 muscle fibers/neuron
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small motor units 3-6 muscle fibert/ neuron 

hands and eyes
large motor units 1000 muscle fibers per/neuron

more strength than control 

calf muscles
neuromuscular junction has a synapse, and synaptic knob

when target cell is a muscle
synapse where cell meets target cell
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schwann cell separates nerve cell from myeline tissue
synaptic knob where it connects to target cell

contains synaptic vesicles
neuromuscular toxins
  • cholinesterase inhibitors
  • tetanus
  • flaccid paralysis
  • botulism
cholinesterase inhibitors
  • found in pe
  • binds to acetylcholinesterase and prevent it from degrading ACH
  • spastic paralysis
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tetanus
  • clostridium tetani
  • glycine stops motor neurons from producing unwanted contractions
  • blocks glycine, and causes overstmulation and spastic paralysis
flaccid paralysis curare

compete with Ach for receptor sites, but do not stimulate the muscle

plant poison
botulism clostridium botulinum

blocks release of Ach causing flaccid paralysis

botox cosmetic
muscle metabolism ATP supply depends on availability of oxygen and organic energy sources

anaerobi fermentation
aerobic respiration
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anaerobic fermentation
  • little atp and toxic lactic acid
  • absence of oxygen
  • not a great source of energy
  • lactic acid
aerobic respiration ends with CO2 and water
32-36 molecules of atp
immediate energy need oxygen supplied by myoglobin
phosphagen system
  • myokinase
  • creatine kinase
  • transfer phoshate from one to another
short-term shift to anaerobic fementaion
30-40 second of max activity
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long term after 40 sec.
respiratory and cardiovascular system " catch up" 
delivers O2 fast enough for aerobic respiratory to meet ATP demands

36 ATP per glucose
muscle fatigue progressive weakness and loss of contractily
  • atp synthesis declines as glycogen is consumed
  • atp shortage slows down the NA and K pumps
  • lactic acid lowers pH of sarcoplasm
  • release of K with each AP causes accumulation of extracellular K
  • nerve fibers use up their ACh
endocrine system chemical messangers that are secreted in the blood
nervous system
  • electrical and chemical
  • sense organs receive information
  • brain and spinal cord processes this information
  • commands issued to muscles and gland cells
2 divisions
  • central and peripheral
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CNS brain and spinal cord
PNS sensory division
motor division
sensory division of PNS carry sensory signals to CNS

Visceral ----internal organs of the body

Somatic---- going to skeletal muscles
motor division of PNS issusing signals out to muscle and glands to cause reaction

visceral--- sympathetic and parasympathetic

somatic 
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sympathetic division of PNS arouse body reaction
increase heart rate and increase respiration
Parasympathetic calming affect
decrease heart rate and respiration
functional classes of nuerons sensory(afferent-towards cns) 
interneurons (confined to CNS)
motor (efferent-leaving CNS)
soma control center of a neuron
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dendrites recieving signals from other neurons 

axon signal next cell in sequence

schwann cell and synaptic knob
neuroglial cell of CNS have more than neurons (50:1)
protect and assist neurons
6 types:
  • cns (astrocytes, ependymal, microglia, oligodendrocytes)
  • PNS ( schwann cells, satellite)
astrocytes
  • have perivascular feet
  • form the blood brain barrier
  • metabolize glucose to lactate
  • secrete nerve profactors that nourish the neurons
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ependymal cell secrets cerebrospinal fluid
microglia wondering cells that macrophages

oligodendrocytes create the myelin sheath
schwann cells produces myelin sheath ins PNS
regeneration
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satellite cells electrical insulation for nerve
regulate the chemical environment
myelination/conduction
  • is segmented: internode and nodes of ranvier
  • bigger diameter of fiber faster
  • small unmyelinated slow
  • large myelinated fast
  • 80% lipid
local potentials
  • small disturbences in the membrane potential when the neuron is stimulate
  • graded, decremental, reversible, excitator, inhibitory
action potential
  • dramatic change because all or nothing, not reversible
  • RMP -70
  • once threshold is reached influxed of sodium to 35
  • once at 35 the repolarization potassium gate open
  • to hyperpolarization 
  • make sure you don't have stimulation immediately after
Generated by Koofers.com
trigger zone when the local potential reaches this causes the numerous of sodium gate to open causing action potential
threshold -55mV
must reach in order to ope the ion gate to have the action potential
neurotrasmitters acetylcholin
amino acids
monoamines
neuropeptides
amino acids gaba 
glycine
aspartic acid
glutamic acid
Generated by Koofers.com
monoamines epinephrine
neorepineprine
dopamine
serotinine
histamine
neuropeptides cause foor cravings
excitatory postsynaptic potential glutamate and asparate
excites the neuron making neuron more likely to fire therfore making it more positive
inhibitory postsynaptic potentials glycine and GABA 
any voltage change away from the threshold and make neuron less likely to follow
Generated by Koofers.com
acetylcholine and norepinephrine act differently depending on the receptors
summations adding up all postsynaptic potentials and responding

temporal and spatial
temporal summation happens when you have intense stimulation by one presynaptic neuron setting of the post synaptic neuron
spatial summation numerous presynaptic neurons simultaneously setting off the postsynaptic neuron
Generated by Koofers.com
synaptic plasticity ability of a synapses to change

synaptic potentiation process of making transmission easier along those pathways
immediate memory ability to hold something in your thoughts for a few minutes

echos
short term few second to several hours can be quickly forgotten if distracted

reasons: titanic stimulation and post-tenanic potentiation
Generated by Koofers.com
titanic stimulation rapid arrival of repetitive
causes calcium to accumulate which causes the release of the neuron transmitters, causing the postsynaptic neuron to fire
post-tenanic potentiation ability to jog your memory
cause calcium stays elevating the the synaptic knobs so little stimulation needed to jog
long-term memory completely change the synapses, new branching of axons and dendrites
medulla oblongata part of brainstem
cortiocospinal tract, inferior olivary nucleus, reticular formation
Generated by Koofers.com
pons ascending sensory tract
descending motor tracts
pathways in and out of cerebellum
reticular formation(sleep, respiration, and posture)
midbrain tectum, tegmentum and substantia nigra
tectum superior colliculi---visual 

inferior colliculi----signals from inner ear to thalamus
tegmentum connections go to and from cerebellum
Generated by Koofers.com
substantia nigra sends inhibitory signals to thalamus and basal nuclei

parkinsons when this is absent
thalamus gateway to cerebral cortex
motor control
memory and emotional functions of the limbic system
hypothalamus mammillary nuclei
pitutary gland

(hormone secretion, autonomic effect, thermoregulations, food and water intake, rhythm of sleep and waking, memory, emotional behavior)
cerebrum frontal---voluntary function
parietal----general sensory
occipital----vision
temporal--- hearing, smell, learning, memory, some education
Insula----understanding spoken language
Generated by Koofers.com
cerebullum inferior peduncle---medula oblonngata

middle peduncle---- pons

superior peducle----- midbrain

(monitors muscles, evaluation of sensory, timekeeping, hearing, planning and scheduling task)
grey matter neural integration

cerebral cortex
basal nuclei (motor control)
limbic
white matter projection tract

commisural tract

association tract
ventricle produces cerebral spinal fluid
each ventricle contains a choroid plaxu
Generated by Koofers.com
cerebrospinal fluid choroid plexus contains epandymal cells containing this

bouyancy, protection, chemical stability
brain barrier system protects blood capullaries (astrocytes)
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List View: Terms & Definitions

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Front
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 AnatomyStudy of form
 examining the structure of the human body
  • inspection
  • palpation
  • auscultation
  • percussion
 Physiologystudy of function

 Hippocrates
  • god's
  • urged to find natural causes of disease
  • father of medicine
 Aristotle
  • Maybe some natural and supernatural causes
 Galen
  • most influential text book of the ancient era
  • learned through animal dissection
 Avicenna Meimonides
  • muslims
  • wrote very influential books
 Versallus
  • first to do a "dissection" with his class
  • dissected human body
 Hooke
  • Microscope
  • simple microscope to look at dead cells
 Leeuwenhook
  • looked at living cells viewed under microscope
 Schwann/Schledin
  • cell theory
 Charles Darwin
  • Evolutions
  • theory of Natural Selection
 evolutions
  • individuals do not evolve only populations
 theory of natural selection
  • how those species originate throughout time
 Vestigal Organs
  • Remnants of organs that were better developed and more functional in ancestors
 Arboreal adaptations
  • treetop
  • mobil shouldeers
  • opposable thumbs made hands prehensile
  • forward-facing eyes-depth preception
  • color-vision
  • larger-brains and good memory
 Bipedalism
  • Skeletal and muscular modifications
  • increased brain volume
  • family life & social changes
 Atom-molecule-macromolecule-organelle-cell-tissue-organ-organsystem-organismHierarchy of complexity
 chemical elements (95% of body weight)oxygen, carbon, hydrogen, nitrogen, calcium & phosphorous
 Minerals (4% body weight)Calcium, Phosphorous, Chlorine, Mg, K, Na, I Fe, Zn, Cu & S
 Electrolytesneeded for nerve & muscles functions are mineral salts
 RadioactityIsotopes
 Isotopes
  • Varieties of an element, same chemical behavior differ in physical behavior
  • breakdown produces dangerous free radicals
 molecules2 or more atoms united by a chemical bond
 Chemical Reaction
  • a process in which a chemical bond is formed or broke
  • Decomposition
  • synthesis

 Decomposition Reactions
  • Large to small 
  • ab > A+B
 synthesisSmall to big
a + b  > ab
 MetabolismAll the chemical reactions of the body

  • catabolism
  • anabolism
 CatabolismEnergy releasing (exergonic) decomposition reactions
 AnabolismEnergy storing (endergonic) synthesis reactions

  • requires energy input
  • production of protein or fat
 Organic MacromoleculesCarbohydrates
lipids
protein
nucleic acid
 Squamous Cellsthin, flat , and often have a bulge where the nucleus is much like the shape of a fried egg
 Polygonal cellsirregularly angular shaped with four, five, or more sides
 Stellate cellnerve cells that have multiple extensions that give them a starlike shape
 Cuboidal Cells squarish and approximately as tall as they are wide
 Columnar Cellsline the intestines and are markedly taller than wide

liver cells are good example
 Spheroidegg cells and fat cells 

round to ovale
 FibrousSkeletal muscle cells
  • threadlike shape
 10 - 15 micrometers in diameterhuman cell size
 100 micrometer in diameteregg cells
 1 meter longnerve cells
 Major constituents of cell
  • Plasma (cell) membrane
  • Organelles
  • cytoskeleton
  • cytosol
  • extracellular fluid
 Plasma Membranemade of proteins and lipids
 Cytosolintercellular fluid
 Diffusion
  • movement of particles from area of high concentration to area of low concentration

  • aka movement down the concentration gradient
 temp, molecular weight, steepness of gradient, membrane surface area, membrane permeabilityfactors that affect the diffusion rate
 Temperatureincrease temp increase the motion
 molecular weightlarger molecules move slower
 steepness of gradientincrease the difference and increase the rate
 membrane surface areaincrease the area increase the rate
 membrane permeabilityincrease the permeability and increase the rate
 osmosisflow of water from side w/ higher water concentration to the side with lower water concentration across a selectively permeable membrane
 hypotonic environmentenvironment has less concentration of solute

cell swells and may burst  (lyse)
 hypertonic environmentenvironment has more concentration of solute

cell may shrink and shrivel  (crenate)
 Isotonic solutioneverything equals inside and outside environments

no change in shape nor size
 Active transportcarrier-mediated trasport of solute through a membrane up (against) its concentration gradient

ATP energy is consumed

examples:  sodium potassium pump keeps K+ concentration higher inside the cell
 sodium potassium pump (ICF, ECF) consumes one ATP and exchanges three Na+ for 2 K+

K+ is higher in 
Na+ is higher in
 Vescular Transportprocesses that move particles through the membrane in vesicles
 Endocytosisvesicular processes that bring material into the cell

phagoyctosis
pinocytosis
receptor
 Phagoctosiscell eating (white blood cells)

 Pinocytosiscell drinking 
 Receptormediated endocytosis----particle bind to specific receptor on plasma membrane
 Exocytosisdischarging material from the cell

example:  discharge of insulin
 receptor mediated endocytosis
  • extracellular molecules bind to receptors on plasma membrane; receptors cluster together
  • plasma membrane sinks inward, forms clathrin-coated pit
  • pit separates from plasma membrane, form clathrin-coated vesicle containing concentrated molecules form ECF
 Neutrophil Phagocytosis5 different types white blood cells 
 Integuma systemprotection

skin, hair, naile
 Skeletal Systemstructure, support
 muscular systemmovement
 lymphatic systemlymph nodes, tonsils, speed, thymus

lympthatic organs are dominated by WBCs
 Respiratory SystemCellular respiration
 urinary systemremoving wastes/ regulates blood pressure
 nervous systemsensory & internal communication
 endocrine systemhormones
 circulatory systemblood flow, distribution of nutrients 

heart and blood vessels

blue blood until it reaches the lungs ; further from heart darker blood
 Digestive systemnutrients breakdown and absorption 

metabolism and disposal and cleansing of blood

 reproductive systemdont need this to live
 anatomical positionstandard frame of reference for anatomical descriptions & dissections

palms are supinated (face foward)
 Sagittal Planeright and left regions
median (midsagittal) plane
 Frontal Planeanterior (front) and Posterior (back) portions
 transverse Planesuperior (upper) and inferior (lower) portions

 ventral/ dorsalgoing toward front/back
 superior/inferiorabove/below
 proximal/distalclose to pt attachment/ far
 medial/lateraltoward inside/ outside
 superficial/deepclose to surface/ far
 homeostasisbody's ability to detect change and activate mechanisms that oppose it.
 negative feedbackkeeps variable close to the set point


example thermoregulation
 positive feedbackleads to greater change in the same directions


example:  child birth
 Epithelium Tissue
  • flat sheet of closely adhering cells on or more cells thick
  • no room for blood vessels
  • lines body cavities and organs
  • constitues most glands
  • basement membrane anchors epithelium to connective tissue
 simple epitheliaall cells touch basement membrane

can be:
simple squamous
simple cuboidal
simple columnar
pseudostratified
 stratified epithelianot all cell touch basement membrane; multiple layers
2 to 20 or more layers of cells

can be:
stratified squamous
stratified cuboidal
stratified columnar
transitional epithelium
 simple squamous
  • type of epithelial tissue
  • flat
  • rapid diffusion or transport of substances
  • secretes serous fluid
  • found in (lungs, kidneys, blood vessels, and lining of body cavities)
 simple cuboidal
  • type of epithelial tissue
  • cube
  • absorption and secretions
  • mucus production and movement
  • liver, thyroid, mammary, and salivary glands, bronchioles, and kidney tubules
 simple columnar
  • type of epithelial tissue
  • very long and column
  • absorption and secretion; movement
  • lining the GI tract, uterus, kidney, and uterine tubes
  • found in goblet cells
 Psudostratified
  • secretes and propels mucus
  • respiratory tract and portions of male urethra
 goblet cellsmucus secreting cells
 stratified squamouskeratinized and non karatinized
 keratinized
  • epidermis; palms and soles heavily keratinized
  • resists abrasion; retards water loss through skin; resists penetration by pathogenic organisms
 nonkeratinized
  • tongue, oral mucosa, esophagus, and vagina
  • resist abrasion and penetration of pathogens
 stratified cuboidal
  • secretes sweat; sperm production and produces ovarian hormones
  • sweat gland ducts; ovarian follicles and seminiferous tubules
 transitional epitheliumchange from round to flat when stretched

example:  ureter and bladder
 connective tissue
  • most cells are not in direct contact with each other
  • highly vascular
  • functions 
  1. binding of organs, support and movement, physical and immune protections, storage, heath production, transport
  • more matrix than cells
four types:  fibrous, loose, dense, supportive

 fibrous CTcells (fibroblast, macrophages, leukocytes, plasma cells, mast cells, adipocytes)

fibers (collagenous, reticular, elastic)
 Macrophagesfibrous cells able to phagocytise
 

 Leukocytesfibrous white blood cells

immune protection

 Plasma Cellsfibrous CT cell that secretes antibodies
 Mast Cellfibrous CT cell secret heparin and histamine
 heparinblood doesnt clot
 histaminewiden blood vessels
 adipocytesfibrous ct  fat cells

store lipids
 collagenous fiberscant stretch

 reticular fiberscoated with glycoprotein
 elastic fibersvery stretchable
 Loose CTAreolar tissue
reticular tissue
adipose tissue

 areolar tissueall cell types present, mostly collagenus fibers

underlies all epithelia, in serous membrane, between muscles, passageways for nerves and blood vessels
 reticular tissuemesh of reticular fibers and fibroblasts

found in lymph nodes, spleen, thymus, and bone marrow
 adipose tissueenergy storage, insulation, cushioning

areolar tissue, reticular tissue, and blood capillaries between cells
 Dense CTDense regular and Dense irregular
 Dense regularall fibers running parallel

tendons and ligaments

 tendonsmuscle to bone

most important to stabilizing joing
 ligamentsbone to bone
 dense irregulardeeper layer of skin; capsules around organs
 supportive CTcartilage
  • hyaline cartilage
  • elastic cartilage
  • fibrocartilage
 hyaline cartilage
  • fine collagen fibers
  • articular cartilage, costal cartilage, trachea, larynx, fetal skeleton
  • eases joint movement, holds airway open, moves vocal cords during speech
 elastic cartilage
  • elastic fibers
  • provides flexible, elastic support
  • external ear and epiglottis
 Fibrocartilage
  • large collagen fibers
  • resists compression and absorbs shock
  • pubic symphysis, menisci, and intervertebral discs
 fluid CTblood 

 bloodplasma
forms :  erythrocytes, leukocyte, and platelets
 erythrocytes
  • red blood cell
  • carry oxygen
 leukocytes
  • white blood cells
  • immunity
 Platelets
  • blood clotting (help clot) when bleeding needs to be stopped
 muscular and nervousexcitable tissues
 nervous tissue
  • specialized for communication by electrical and chemical signals
  • neuron parts:  neurosoma, dendrite, axon
 neurosomacell body
 dendrites
  • receive signals
  • transmits to neurosoma
 axonnerve fiber
  • sends outgoing signals 
  • one of the longest cells
 muscular tissue
  • elongated cells specialized to contract
  • creates movement involved in body and limb movement, digestion, waste, elimination, breathing, speech, and blood circulation
  • produces movement witha  good source of heat
three types
  • skeletal, cardiac, smooth
 skeletal muscle
  • most attach to bone
  • have striation
  • voluntary
 cardiac muscle
  • mysocytes/cardiocytes-shorter, branched , and notched at ends
  • on centrally located nucleus
  • intercalated discs
  • striated and involuntary
 smooth muscles
  • lacks striations and is involuntary
  • visceral muscle
  • propels contents through an organ regulates diameter of blood vessels
  • reacts to hormones

example:  labor
 endocrine Glandslose contact with surface

  • secrete (hormones) directly into blood
  • thyroid, adrenal and pituitary glands
 exocrine glandsmaintain contact with body surface by way of a duct

type: 
  • serous
  • mucous
  • mixed
  • cytogenic
 serous glandsproduce thin, watery secretions

type of exocrine gland

 mucous glandsfound on tongue and roof of mouth

type of exocrine glands
 mixed glandsboth serous and mucous glands

 cytogenic glandsrelease whole cells

sperm and egg cells
 methods of secretionmerocrine glands

apocrine glands

holocrine glands
 merocrine glandsvesicles release secretion by exocytosis
  • tear glands, pancreas, gastric glands, and others

 apocrine glandsmerocrine mode of secretion
  • axillary sweat glands, mammary glands
 holocrine glandcells accumulate a product and the entire cell disintegrates
  • oil glands of scalp and glands of eyelids
 epidermiskaratinized stratified squamous

5 layers:  stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, stratum basale

  • lacks blood vessels
  • diffusion of nutrients
  • nerve endings
  • cells
  • karatinocytes----keratin
 stratum corneum
  • 30 layers
  • resistant to abrasion, penetration, and water loss

 stratum lucidum
  • only in thick skin
  • contains eleidin
  • no nucleus or other organelles
 stratum granulosum3-5 layers thick

keratohyalin granule
  • filaggrin
  • epidermal water barrier
 stratum spinosumthickest in most skin

produces keratin filaments

8-10 cells thick
 stratum basaleone cell layer thick

stem cells divide keratinocytes

melanocytes----melanin

tactile (merkel) cells----touch receptor cells
 dermis
  • Loose CT
  • collagen with elastic fiber, reticular fibers, and fibroblasts
  • blood vessels, sweat glands sebaceous glands and nerve endings hair follicles and nail root
  • piloerector muscles
  • dermal papillae-frictions ridges

 malignant melanoma
  • arises from melanocytes
  • not common by most deadly 
  • metastasizes rapidly
  • life expectancy----6 months
  • spreads quicker than most
 basal cell carcinomamost common

arises from cells in stratum basal
 squamous cell carcinoma
  • arises from keratinocytes from stratum spinosum
  • can spread to lymph nodes and become very dangerous
 papillary layer
  • layer of dermis
  • areolar tissue
  • mobility of leukocytes (white blood cells)
  • protect you from anything coming through the dermis
  • most blood vessels supplying
 reticular layer
  • dense, irregular CT
  • stretch marks
 hypodermis
  • mostly areolar and adipose
  • binds skin to tissues
  • drugs introduced by injection
  • 8% thicker in women than men
 cyanosisdeficiency of oxygen in blood

cold weather, airway abstruction
 erythemadilated cutaneous vessels


hot weather, exercise, anger
 pallorlittle blood flow through the skin


low blood pressure, anemic, circulatory shock
 albinismgenetic lack of melanin
 jaundiceexcess of bilirubin in blood


yellowing of skin, eye
 hematomamass of clotted blood


bruise, hicky

 flatcurly hair shape
 roundstraight hair shape

 red hairmore phamelanin than eumalanin
 black hairhigh concentration of eumalanin
 blonde hairvery little eumalanin more phamelanin
 greyabsence of melanin

cortex become hollowed out
 debridementremoval of eschar
 1st degree burnhavent gone through the skin
 2nd degree burngone throught the dermis
 3rd degree burnneed skin graphs

burn through the dermis and epidermis down to bone
 functions of the skin
  • resistance to trauma and infection
  • other barrier functions
  • Vitamin D synthesis
  • sensation
  • thermoregulation
  • nonverbal communication
  • transdermal absorption
 resistance to trauma and infectionkeratin

acid mantle
 other barrier functionswaterproofing
UV radiation
harmful chemicals
 Vitamin D synthesisskin first step

liver and kidneys complete process
 sensationskin is our most extensive sense organ
 thermoregulationthermoreceptors

vasoconstriction/ vasodilation
 nonverbal communicationacne, birthmark, or scar
 Transdermal absorptionadministration of certain drugs steadily through this skin----adhesive patches
 Long, short, flat, irregular 
 Long bonerigid levers acted upon by muscle (femur and ulna)
structure:
  • Periosteum & endosteum
  • nutrient foramina
  • Epiphyses & diaphysis
  • compact & spongy
  • marrow cavity
  • articular cartilage
 periosteumouter layer of long bone
 endosteuminner layer of long bone

cells that can deposit or breakdown
 nutrient foraminablood vessels are allowed to penetrate the bones
 epiphyseslarge end of long bone
 diaphysisshaft of  long bone
 epiphysial lineseperates piphyses from diaphysis 

in adults
 compactsurface of all bones
 spongyin the ends of long bones
 marrow cavityin the middle and contains the marrow
 short bones
glide across one another in multiple directions

carpals and tarsals
 flat bonesprotect soft organs

scapula, sternum, cranial, ribs
 irregular bonesskull bones

vertebrate, sphenoid, ethnoid
 bone marrowred----- myeloid tissue
(child)

yellow----(adults)
 four principle types of bone cellsosteogenic cell
osteoblasts
osteocytes
osteoclast
 osteogenic cellgive rise to osteoblast

stem cell
 osteoblastbuil

start producing matrix to form bone

becomes trapped in matrix and becomes osteocytes
 osteocytesmature bone cell
 osteoclastcatastrophe

same stem cell as blood

develops from stem cells from a different origin

surface of bone

bone dissolving cells
 compact bone
  • lacunae
  • canaliculi
  • central canal
  • osteon
  • interstitial lamella
 spongy bone
  • very few osteon
  • made up or trabeculae
  • needs strength but not a lot of weight
  • develops along the lines of stress
 osteogenesisin the human fetus and infant, bone develops by two methods:

intramembranous ossification
endochondral ossification

 interstitial growthpart of bone growth

bones increase in length
 appositional growththe deposition of new bone at the surface
 bone remodelingoccurs throughout life 10% per year
 Achondroplastic dwarfismfailure of cartilage growth in metaphysis
 pituitary dwarfismlack of growth hormone
 calcium homeostasisis regulated by three hormones: calcitriol, calcitonin, and parathyroid hormone
 hypocalcemiablood calcium deficiency

Na enters cells to easily and excites
muscle spasms, tenisis
 hypercalcemiablood calcium excess

Na channels less responsive, nerve and muscular tissue
depress and slugish 

very rare
 calcitriol
  • form of vitamin D through the skin, liver, and kidney
  • hormone that stars with the skin from the sunlight
  • kidney then converts vitamin to this
  • its releades to raise the concentration of calcium

  • makes bone resorptions
  • reduce excretion of ca
  • make stomach and intestine absorb more calcium
 calcitonindecreases blood calcium back to normal
produced by the thyroid gland
 parathyroid hormone secretioncorrection for hypocalcemia
  • increased osteoclast
  • reduced osteoblast
  • more urinary phosphate excretion
  • less urinary calcium excretion
 stress fractureabnormal trauma to a bone
 pathological fractureweakend by disease
 nondisplacedcracked but bones still aligned
 displacedbones are not aligned completely broken
 comminutedbones broken in 3 or more places

 greenstickincomplete fractured causing stress on another bone
 closed treatmentno surgery 
 opened treatmentplates screws to fix
 boney joints
  • immovable joint
  • gap between bones ossify
  • fibrous or cartilaginous joint
 fibrous jointsadjacent bones are bounded by collagen fibers
three kind:
  • sutures
  • gomphoses
  • syndesmosis
 sutures
  • immovable
  • bind bones in skull
  • serrate, lap and plane suture
 serrate sutureinterlocking wavy lines,

coronoid, sagittal, squamous, lamnoid
 lap suturemiter joint

temporal and squamous

 plane suturebutt joint

palatine bone
 gomphosesattaches tooth to socket
 syndesmosesbound by longer collagen fibers

most movable (between radius and ulna)

least movable (tibia to fibula)
 Cartilaginous jointstwo bones linked by cartilage

synchondroses and symphysis

first ribs attached
 synchondroseshyaline cartilage
 symphysisfibrocartilage

between the vertebrate
 synovial joints
  • two bones separated by joint cavity filled with synovial fluid
  • joint capsule
  • accessory structures
  • ball and socket, condyler, saddle, plane, hindge, pivet
 bursa-synovial fluid filled sacbetween adjacent muscle and help cushion muscle
 tendon sheathcylindrical covers tendon
 ball and sockethead in a cop

hip and shoulder (only one)

multiaxial
 condylarone bone has a compact surface fits into a compression on the other side

radial and carpals, phalanges and metacarpals

bioxial joint
 saddle jointboth bones have depression that fit each other
  • trapizia metacarpas
  • sternum and clavical

bioxial
 plane jointsgliding joints
both have a flat surface
  • carpals and tarsals
  • articulation processes of vertebrate 

bioxial

 hidge jointsone bone has a compact surface and fits into a depresion

  • knee, elbow, and fingers and toes

monoxial
 pivet jointradius and ulna

occipital

monoxial
 zero positionposition of a joint when in standard anatomical position
 flexiondecreses joint angle
 extensionreturn joint to zero
 hyperextensionsincrease joint angle beyond zero position
 abductionmovement away from midline of body
 adductionmovement towards midline of body
 elevationmovement that raises the body vertically
 depressionlowers the body vertically
 protractionanterior movement of body
 retractionposterior movement of body
 circumductionone end stays stationary and other makes a circular motion
 shoulder
  • glenohumeral joint
  • biceps brachii and rotator cuff
  • five ligaments:  coracohumeral, transverse humeral, glenohumeral
 elbow
  • hinge joint
  • radial collateral ligament
  • ulnar collateral ligament
  • radioulnar joint
 hip coxal joint
  • deeper sockets
 knee jointtibofemoral joint-----hidge joint

patellorfemoral joint------gliding
 orbicularis oculio---eyelids

i---eyelids
 orbicularis oriso & i----lip
 sternocleidomastoidflex neck

o----clavicle

i-----mastoid process
 proteins that make up skeletal muscle
  • contractile, regulatory, accessory, myofilaments
 contractilemyosin and actin
 regulatory proteinstropomyosin and troponin
 accessory proteinsdystrophin
 thick myofilamentmyosin molecule
 elastic myofilamenttitin-  anchors thick to z disc
 tropomyosin
blocks active sites
 troponincalcium-binding protein
 denervation atrophyshrinkage of paralyzed muscle
 somatic motor neuronseach fiber only has one neuron but one neuron can be connected to many fibers
 motor unitone nerve fiber and all the muscle fibers innervated
 muscle fibers of one motor unit
  • contract in unison
  • weak contraction over wide area
  • ability to sustain long-term contraction
 average motor unit200 muscle fibers/neuron
 small motor units3-6 muscle fibert/ neuron 

hands and eyes
 large motor units1000 muscle fibers per/neuron

more strength than control 

calf muscles
 neuromuscular junctionhas a synapse, and synaptic knob

when target cell is a muscle
 synapsewhere cell meets target cell
 schwann cellseparates nerve cell from myeline tissue
 synaptic knobwhere it connects to target cell

contains synaptic vesicles
 neuromuscular toxins
  • cholinesterase inhibitors
  • tetanus
  • flaccid paralysis
  • botulism
 cholinesterase inhibitors
  • found in pe
  • binds to acetylcholinesterase and prevent it from degrading ACH
  • spastic paralysis
 tetanus
  • clostridium tetani
  • glycine stops motor neurons from producing unwanted contractions
  • blocks glycine, and causes overstmulation and spastic paralysis
 flaccid paralysiscurare

compete with Ach for receptor sites, but do not stimulate the muscle

plant poison
 botulismclostridium botulinum

blocks release of Ach causing flaccid paralysis

botox cosmetic
 muscle metabolismATP supply depends on availability of oxygen and organic energy sources

anaerobi fermentation
aerobic respiration
 anaerobic fermentation
  • little atp and toxic lactic acid
  • absence of oxygen
  • not a great source of energy
  • lactic acid
 aerobic respirationends with CO2 and water
32-36 molecules of atp
 immediate energy needoxygen supplied by myoglobin
phosphagen system
  • myokinase
  • creatine kinase
  • transfer phoshate from one to another
 short-termshift to anaerobic fementaion
30-40 second of max activity
 long termafter 40 sec.
respiratory and cardiovascular system " catch up" 
delivers O2 fast enough for aerobic respiratory to meet ATP demands

36 ATP per glucose
 muscle fatigueprogressive weakness and loss of contractily
  • atp synthesis declines as glycogen is consumed
  • atp shortage slows down the NA and K pumps
  • lactic acid lowers pH of sarcoplasm
  • release of K with each AP causes accumulation of extracellular K
  • nerve fibers use up their ACh
 endocrine systemchemical messangers that are secreted in the blood
 nervous system
  • electrical and chemical
  • sense organs receive information
  • brain and spinal cord processes this information
  • commands issued to muscles and gland cells
2 divisions
  • central and peripheral
 CNSbrain and spinal cord
 PNSsensory division
motor division
 sensory division of PNScarry sensory signals to CNS

Visceral ----internal organs of the body

Somatic---- going to skeletal muscles
 motor division of PNSissusing signals out to muscle and glands to cause reaction

visceral--- sympathetic and parasympathetic

somatic 
 sympathetic division of PNSarouse body reaction
increase heart rate and increase respiration
 Parasympatheticcalming affect
decrease heart rate and respiration
 functional classes of nueronssensory(afferent-towards cns) 
interneurons (confined to CNS)
motor (efferent-leaving CNS)
 somacontrol center of a neuron
 dendritesrecieving signals from other neurons 

 axonsignal next cell in sequence

schwann cell and synaptic knob
 neuroglial cell of CNShave more than neurons (50:1)
protect and assist neurons
6 types:
  • cns (astrocytes, ependymal, microglia, oligodendrocytes)
  • PNS ( schwann cells, satellite)
 astrocytes
  • have perivascular feet
  • form the blood brain barrier
  • metabolize glucose to lactate
  • secrete nerve profactors that nourish the neurons
 ependymal cellsecrets cerebrospinal fluid
 microgliawondering cells that macrophages

 oligodendrocytescreate the myelin sheath
 schwann cellsproduces myelin sheath ins PNS
regeneration
 satellite cellselectrical insulation for nerve
regulate the chemical environment
 myelination/conduction
  • is segmented: internode and nodes of ranvier
  • bigger diameter of fiber faster
  • small unmyelinated slow
  • large myelinated fast
  • 80% lipid
 local potentials
  • small disturbences in the membrane potential when the neuron is stimulate
  • graded, decremental, reversible, excitator, inhibitory
 action potential
  • dramatic change because all or nothing, not reversible
  • RMP -70
  • once threshold is reached influxed of sodium to 35
  • once at 35 the repolarization potassium gate open
  • to hyperpolarization 
  • make sure you don't have stimulation immediately after
 trigger zonewhen the local potential reaches this causes the numerous of sodium gate to open causing action potential
 threshold-55mV
must reach in order to ope the ion gate to have the action potential
 neurotrasmittersacetylcholin
amino acids
monoamines
neuropeptides
 amino acidsgaba 
glycine
aspartic acid
glutamic acid
 monoaminesepinephrine
neorepineprine
dopamine
serotinine
histamine
 neuropeptidescause foor cravings
 excitatory postsynaptic potentialglutamate and asparate
excites the neuron making neuron more likely to fire therfore making it more positive
 inhibitory postsynaptic potentialsglycine and GABA 
any voltage change away from the threshold and make neuron less likely to follow
 acetylcholine and norepinephrineact differently depending on the receptors
 summationsadding up all postsynaptic potentials and responding

temporal and spatial
 temporal summationhappens when you have intense stimulation by one presynaptic neuron setting of the post synaptic neuron
 spatial summationnumerous presynaptic neurons simultaneously setting off the postsynaptic neuron
 synaptic plasticityability of a synapses to change

 synaptic potentiationprocess of making transmission easier along those pathways
 immediate memoryability to hold something in your thoughts for a few minutes

echos
 short termfew second to several hours can be quickly forgotten if distracted

reasons: titanic stimulation and post-tenanic potentiation
 titanic stimulationrapid arrival of repetitive
causes calcium to accumulate which causes the release of the neuron transmitters, causing the postsynaptic neuron to fire
 post-tenanic potentiationability to jog your memory
cause calcium stays elevating the the synaptic knobs so little stimulation needed to jog
 long-term memorycompletely change the synapses, new branching of axons and dendrites
 medulla oblongatapart of brainstem
cortiocospinal tract, inferior olivary nucleus, reticular formation
 ponsascending sensory tract
descending motor tracts
pathways in and out of cerebellum
reticular formation(sleep, respiration, and posture)
 midbraintectum, tegmentum and substantia nigra
 tectumsuperior colliculi---visual 

inferior colliculi----signals from inner ear to thalamus
 tegmentumconnections go to and from cerebellum
 substantia nigrasends inhibitory signals to thalamus and basal nuclei

parkinsons when this is absent
 thalamusgateway to cerebral cortex
motor control
memory and emotional functions of the limbic system
 hypothalamusmammillary nuclei
pitutary gland

(hormone secretion, autonomic effect, thermoregulations, food and water intake, rhythm of sleep and waking, memory, emotional behavior)
 cerebrumfrontal---voluntary function
parietal----general sensory
occipital----vision
temporal--- hearing, smell, learning, memory, some education
Insula----understanding spoken language
 cerebulluminferior peduncle---medula oblonngata

middle peduncle---- pons

superior peducle----- midbrain

(monitors muscles, evaluation of sensory, timekeeping, hearing, planning and scheduling task)
 grey matterneural integration

cerebral cortex
basal nuclei (motor control)
limbic
 white matterprojection tract

commisural tract

association tract
 ventricleproduces cerebral spinal fluid
each ventricle contains a choroid plaxu
 cerebrospinal fluidchoroid plexus contains epandymal cells containing this

bouyancy, protection, chemical stability
 brain barrier systemprotects blood capullaries (astrocytes)