Lecture Slides on The Genetics Revolution in The Life Sciences | BIOLOGY 206, Study notes of Genetics

Download Lecture Slides on The Genetics Revolution in The Life Sciences | BIOLOGY 206 and more Study notes Genetics in PDF only on Docsity! Introduction to Genetic Analysis TENTH EDITION CHAPTER 1 The Genetics Revolution in the Life Sciences Life on Earth — Rich and Complex Figure 1-1 roduction to Genetic Analysis, Tenth Edition 012 W. H. Freeman and Company DNA is biological information 1. Ability to replicate 2. Translation 3. Diversity of structure 4. Mutability Four Properties of the “Information Structure” of Biological Organisms The nuclear genome Eukaryotic cell Nuclear chromosomes DNA-protein supercoil SPLASH AHYLA IER Lane ee DNA PE ee en oe ference a OE —— Gene Gene Figure 1-5 Introduction to Genetic Analysis, Tenth Edition © 2012 W. H. Freeman and Company A diploid genome visualized diploid organism – two identical chromosome sets homologous chromosomes or homologs – a chromosome pair contained within a diploid, “nearly identical” DNA sequence haploid organism – one chromosome set The flow of information in a eukaryotic cell Covered in Chapters 7, 8, and 9 Evolutionary tree based on comparisons of cytochrome c DNA 1.3 Genetics and Evolution Covered in Chapters 18, 19, and 20 DNA-based migration routes of Homo sapiens Arctic o#z es Ocean ate North Atlantic Ocean ; South . Pacific Ocean @ South Atlantic Ocean Y chromosome DNA —— Mitochondrial DNA ee Figure 1-20 Introduction to Genetic Analysis, Tenth Edition © 2012 W. H. Freeman and Company A DNA fingerprint 1.6 Genetics Changes Society 1.7 Genetics and the Future A transgenic organism Nikhil et al., Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic Profiling. 2011. J. Clin. Oncol. 29: 3085-3096. A 38 yr old man with BRAF- mutant melanoma and subcutaneous metastatic deposits. (A) before treatment with PLX4032, (B) after 15 weeks of therapy with PLX4032, and (C) relapse after 23 weeks of therapyPLX4032 = targeted cancer therapy drug.