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Physiology Exam #3 Contraction of Smooth Muscle - Flashcards

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Class:BIOL 2150 - PRINCIPLES OF PHYSIOLOGY
Subject:Biology
University:The Richard Stockton College of New Jersey
Term:Fall 2012
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Step One extracellular calcium (Ca++) is needed

-SR is too small and cant store enough Ca++ 

-not enough calcium leads to hypocalcemia 
Step Two calcium binds to calmodulin and activates MLCK (myosin light chain kinase)

-no troponin
Step Three Myosin Light Chain Kinase (MLCK)  enhances myosin ATPase activity by phosphorylating light protein chains near the myosin head.
 
Step Four Calcium and calmodulin  and MLCK activate myosin heads

- attaches Pi
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Step Five cross bridges form with actin 


( light protein chains on myosin head are phosphorylated to allow this binding)
Step Six high myosin ATPase activity occurs = causes the binding with actin
Step Seven (Relaxation) dephosphorylation of myosin light chain phosphatase (MLCP)

-stops ATPase
Step Eight (Relaxation) Ca++ and Na+ exchange to get calcium out of cytoplasm

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Step Nine (Relaxation) calmodulin uncomplexes
Step Ten (relaxation) MLCK inactivated

(myosin light chain kinase) 
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 Step Oneextracellular calcium (Ca++) is needed

-SR is too small and cant store enough Ca++ 

-not enough calcium leads to hypocalcemia 
 Step Twocalcium binds to calmodulin and activates MLCK (myosin light chain kinase)

-no troponin
 Step ThreeMyosin Light Chain Kinase (MLCK)  enhances myosin ATPase activity by phosphorylating light protein chains near the myosin head.
 
 Step FourCalcium and calmodulin  and MLCK activate myosin heads

- attaches Pi
 Step Fivecross bridges form with actin 


( light protein chains on myosin head are phosphorylated to allow this binding)
 Step Sixhigh myosin ATPase activity occurs = causes the binding with actin
 Step Seven (Relaxation)dephosphorylation of myosin light chain phosphatase (MLCP)

-stops ATPase
 Step Eight (Relaxation)Ca++ and Na+ exchange to get calcium out of cytoplasm

 Step Nine (Relaxation)calmodulin uncomplexes
 Step Ten (relaxation)MLCK inactivated

(myosin light chain kinase) 
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