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Immunology Test 2 [incomplete] - Flashcards

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Class:MICRO 414 - BASIC IMMUNOLOGY
Subject:MICROBIOLOGY
University:Clemson University
Term:Spring 2012
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Antigen Molecules that can be bound by antibodies or T cell receptors
Antigenicity Ability to specifically bind to antibody or T cell receptor
Immunogenicity Ability to induce a humoral/cell-mediated immune response
All ________ are antigens Immunogens
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Peak immune response depends on ___ and ___ Dose and Route
Adjuvents enhance immunology
  • antigen persistence prolonged
  • co-stimulatory signals enhanced
  • local inflammation increased
  • stimulate non-specific proliferation of lymphocytes
Epitopes Antigenic determinants of an antigen
Active regions on immunogens


B cells recognize epitopes ________. in their native form
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T cells recognize epitopes________. in a form of peptide/MHC complex
Haptens Small molecule that is Antigenic
NOT immunogenic
Attaches to carrier
Superantigens Viral or bacterial protein
Exogenous superantigen Soluble protein from bacterium
Exotoxins

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Endogenous Superantigen Membrane proteins produced by some viruses
Antibody Ig - Immunoglobulin
Antibodies distinguish ______ from other antigens. Epitopes/immunogens
Antibodies are composed of ___ and ___ chains. Light and heavy

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There are ____ variable regions (domains) on each chain. (antibodies) 1
VL and VH are the _________. (antibodies) Antigen binding sites
Chains held together by ______ bonds. (antibodies) Disulfide
The hinge region contains _____. (antibodies) Hydrogen chains
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Papain digests monomer Ig to produce ____ and ____. 2 Fab
1 Fc
Pepsin digest of monomer Ig produces _____ and _____. 1 F(ab')2
Small peptides
"Isotype" Antibody class
Immunoglobulins serum proteins w/ antibody activity

  • IgG
  • IgA
  • IgD
  • IgM
  • IgE
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Antibody classes are determined by the _____. Heavy chain
IgG makes up ___% total serum 70-75
In IgG, main differences in AA sequence are clustered at the _________. Hinge region
_______ has a higher molecular weight due to its elongated hinge region. IgG3
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IgG1, IgG2, and IgG3 involved in ______ transfer. Placental
IgG1 binds to ________. Macrophages
Phagocytes
Protein A of S. Aureus

IgG2 has a weak ________. Binding complement
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 AntigenMolecules that can be bound by antibodies or T cell receptors
 AntigenicityAbility to specifically bind to antibody or T cell receptor
 ImmunogenicityAbility to induce a humoral/cell-mediated immune response
 All ________ are antigensImmunogens
 Peak immune response depends on ___ and ___Dose and Route
 Adjuventsenhance immunology
  • antigen persistence prolonged
  • co-stimulatory signals enhanced
  • local inflammation increased
  • stimulate non-specific proliferation of lymphocytes
 EpitopesAntigenic determinants of an antigen
Active regions on immunogens


 B cells recognize epitopes ________.in their native form
 T cells recognize epitopes________.in a form of peptide/MHC complex
 HaptensSmall molecule that is Antigenic
NOT immunogenic
Attaches to carrier
 SuperantigensViral or bacterial protein
 Exogenous superantigenSoluble protein from bacterium
Exotoxins

 Endogenous SuperantigenMembrane proteins produced by some viruses
 AntibodyIg - Immunoglobulin
 Antibodies distinguish ______ from other antigens.Epitopes/immunogens
 Antibodies are composed of ___ and ___ chains.Light and heavy

 There are ____ variable regions (domains) on each chain. (antibodies)1
 VL and VH are the _________. (antibodies)Antigen binding sites
 Chains held together by ______ bonds. (antibodies)Disulfide
 The hinge region contains _____. (antibodies)Hydrogen chains
 Papain digests monomer Ig to produce ____ and ____.2 Fab
1 Fc
 Pepsin digest of monomer Ig produces _____ and _____.1 F(ab')2
Small peptides
 "Isotype"Antibody class
 Immunoglobulinsserum proteins w/ antibody activity

  • IgG
  • IgA
  • IgD
  • IgM
  • IgE
 Antibody classes are determined by the _____.Heavy chain
 IgG makes up ___% total serum70-75
 In IgG, main differences in AA sequence are clustered at the _________.Hinge region
 _______ has a higher molecular weight due to its elongated hinge region.IgG3
 IgG1, IgG2, and IgG3 involved in ______ transfer.Placental
 IgG1 binds to ________.Macrophages
Phagocytes
Protein A of S. Aureus

 IgG2 has a weak ________.Binding complement
   
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