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NPB 101 Lec 1 - Flashcards

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Class:NPB 101 - Systemic Physiology
Subject:Neurobiology,Physio & Behavior
University:University of California - Davis
Term:Fall 2010
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Levels of organization (6) Chemical (molecular)--> cellular (cell is basic unit of life)--> tissue--> organ--> system--> organism
What are the principles of physiology? (2) 1. Homeostasis 2. Regulation
Homeostasis (2) 1. a dynamic steady-state of the internal environment. 2. not all physiological variables are homeostatically maintained
Regulation (2) 1. How we obtain homeostasis 2. Feedback [negative (most common) or positive]
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Homeostasis (broad) (3) 1. defines as maintenance of a relatively stable internal environment [dynamic steady-state (input and output in equilibrium)] 2. homeostasis is essential for survival and function of all cells. 3. each cell contributes to maintenance of a relatively stable internal environment
Some examples of factors homeostatically regulated include: (7) 1. concentration of nutrient molecules 2. concentration of O2 and CO2 3. concentration of waste products 4. pH 5. concentration of water, salt, and other electrolytes 6. volume and pressure 7. body temperature
FACT Body cells are contained in water internal environment through which life-sustaining exchanges are made
Extracellular fluid (ECF) (2) 1. fluid environment in which the cells live (fluid outside the cells) 2. Two components: plasma, interstitial fluid
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Intracellular fluid (ICF) (1) 1. fluid contained within all body cells
Cycle of homeostasis Body system--> maintain --> homeostasis--> is essential for survival of--> cells--> make up--> body systems
In order to maintain homeostasis, regulatory systems must be able to: (3) 1. Detect deviations from normal in the internal environment that need to be held within narrow limits 2. integrate this information with other relevant information 3. make appropriate adjustments in order to restore factor to its desired value
Negative feedback system (2) 1. primary type of homeostatic controls 2. opposes initial change
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What are the components of the negative feedback system? (3) 1. sensor- monitors level of a regulated variable. 2. integrator (control center) (compares sensor's input with a set point) 3. effector (makes a response to produce a desired effect)
Positive feedback system (2) 1. amplifies an initial change 2. does not occur as often as negative feedback system [ex: uterine contractions become increasingly stronger until the birth of the baby]
Disruptions in Homeostasis (2) 1. can lead to illness and death 2. pathophysiology (abnormal functioning of the body associated with disease)
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 Levels of organization (6)Chemical (molecular)--> cellular (cell is basic unit of life)--> tissue--> organ--> system--> organism
 What are the principles of physiology? (2)1. Homeostasis 2. Regulation
 Homeostasis (2)1. a dynamic steady-state of the internal environment. 2. not all physiological variables are homeostatically maintained
 Regulation (2)1. How we obtain homeostasis 2. Feedback [negative (most common) or positive]
 Homeostasis (broad) (3)1. defines as maintenance of a relatively stable internal environment [dynamic steady-state (input and output in equilibrium)] 2. homeostasis is essential for survival and function of all cells. 3. each cell contributes to maintenance of a relatively stable internal environment
 Some examples of factors homeostatically regulated include: (7)1. concentration of nutrient molecules 2. concentration of O2 and CO2 3. concentration of waste products 4. pH 5. concentration of water, salt, and other electrolytes 6. volume and pressure 7. body temperature
 FACTBody cells are contained in water internal environment through which life-sustaining exchanges are made
 Extracellular fluid (ECF) (2)1. fluid environment in which the cells live (fluid outside the cells) 2. Two components: plasma, interstitial fluid
 Intracellular fluid (ICF) (1)1. fluid contained within all body cells
 Cycle of homeostasisBody system--> maintain --> homeostasis--> is essential for survival of--> cells--> make up--> body systems
 In order to maintain homeostasis, regulatory systems must be able to: (3)1. Detect deviations from normal in the internal environment that need to be held within narrow limits 2. integrate this information with other relevant information 3. make appropriate adjustments in order to restore factor to its desired value
 Negative feedback system (2)1. primary type of homeostatic controls 2. opposes initial change
 What are the components of the negative feedback system? (3)1. sensor- monitors level of a regulated variable. 2. integrator (control center) (compares sensor's input with a set point) 3. effector (makes a response to produce a desired effect)
 Positive feedback system (2)1. amplifies an initial change 2. does not occur as often as negative feedback system [ex: uterine contractions become increasingly stronger until the birth of the baby]
 Disruptions in Homeostasis (2)1. can lead to illness and death 2. pathophysiology (abnormal functioning of the body associated with disease)
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