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NPB 101 Lecture 27 - Flashcards

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Class:NPB 101 - Systemic Physiology
Subject:Neurobiology,Physio & Behavior
University:University of California - Davis
Term:Fall 2010
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SA nodal cell= pacemaker potential
___________ cell slowly and spontaneously becomes more positive until membrane reaches threshold value SA nodal
During first half of period of pacemaker potential, there is spontaneous decrease of permeability of SA nodal cell membranes for ___________ potassium
During pacemaker potential, ___________ permeability decreases, loss of this ion, causing membrane to become more positive potassium
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What also happens during the first half of the pacemaker period is an increase in the permeability for ___________ channels sodium
The sodium channels that are open during the first half of the pacemaker period are called ___________ funny sodium channels
Opening of ___________ allows movement of positive ion from the outside of the cell toward the inside funny sodium channels
During the last half of the period of the pacemaker potential, there is an increase in the permeability for the membrane of ___________ calcium
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Calcium ___________ the SA nodal cells enters
T channels stands for: Temporary
The calcium channels that open during last half o the period of the pacemaker potential are called: T-channels
___________ potential is the phenomena that causes the SA node to spontaneously fire AP Pacemaker
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The ___________ has the highest spontaneous rate of AP firing SA node
TF It is possible if the SA node is damaged or not working properly, then another cell excitatory part of the heart/tissue will take over and function as pacemaker true
If the SA node is not working properly, then ___________ will function as a pacemaker AV node
___________ has the next highest spontaneous rate of discharge after SA node AV node
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___________ paces all of the other excitable cells in the heart SA node
During ventricular AP, phase ___ is the period of the resting membrane potential 4
During ventricular AP, under normal circumstances, during phase ___ the membrane DOES come to a stable isoelectric potential 4
During phase 4 of ventricular AP, this period of time shows a relatively high permeability of _____________ potassium
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During phase ___ of ventricular AP, potassium continuously leaks from interior to exterior 4
During phase 4 of ventricular AP, the type of potassium channel open is called: Leaky potassium channels
During point ___ of ventricular AP, muscle fiber becomes stimulated 0
During phase ___ of ventricular AP, membrane fires the rapid upstroke of the AP 0
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Increase in membrane potential during phase 0 of ventricular AP is caused by rapid increase in the permeability of muscle fibers for _____________ sodium
During phase 0 of ventricular AP, there is a FAST opening of _____________ channels sodium
During ventricular AP, phase ___ is a brief period of repolarization 1
Phase 1 of ventricular AP is caused by a decrease in the permeability for _____________ sodium
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During phase 1 of ventricular AP, there is an increase in permeability for _____________ potassium
During phase 1 of ventricular AP, potassium is leaving the cell, and brief repolarization brings membrane potential back to _____________ negative
What are the potassium channels called that are open during phase 1 of ventricular AP? temporary potassium channels
What two things occur that cause a brief repolarization during phase 1 of ventricular AP? Decrease permeability of sodium and increased permeability for potassium
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During phase ___ of ventricular AP, the membrane becomes isoelectric for a long period of time 2
Phase ___ of ventricular AP is called the PLATEAU of the myocardial cell of the AP 2
During phase 2 of ventricular AP, there is an increase in permeability for _____________ calcium
The calcium channels that are open during phase 2 of ventricular AP are called: L- [long lasting] calcium channels
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L-calcium channels stand for: long lasting
TF During phase 2 of ventricular AP, increase in the movement from ECL causes additional release of calcium from calcium stores in the SR true
During phase 2 of ventricular AP, there is a decrease in the permeability of cell for _____________ potassium
During phase 2 of ventricular AP, combination of what keeps membrane potential at positive values for a long period of time? (2) Increase in permeability for calcium through L-channels and decrease in permeability for potassium
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During phase 2 of ventricular AP, there is a slow, long lasting influx of _____________ calcium
Phase ___ of ventricular AP is shown by a period of rapid repolarization 3
During phase 3 of ventricular AP, there is a decrease in permeability of _____________ through long lasting channels calcium
During phase ___ of ventricular AP, there is a decrease in permeability of calcium through long lasting channels 3
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During phase 3 of ventricular AP, there is an increase in permeability for _____________ through ordinary channels potassium
During phase 3 of ventricular AP, as permeability for _____________ increases, the membrane can begin to fall and return to resting levels potassium
TF Cannot stimulate cardiac muscle cell and cause summation--- ABSOLUTE REFRACTORY PERIOD true
Almost entire duration of cardiac muscle AP, the membrane is _____________ refractory to further stimulation absolutely
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 SA nodal cell= pacemaker potential 
 ___________ cell slowly and spontaneously becomes more positive until membrane reaches threshold valueSA nodal
 During first half of period of pacemaker potential, there is spontaneous decrease of permeability of SA nodal cell membranes for ___________potassium
 During pacemaker potential, ___________ permeability decreases, loss of this ion, causing membrane to become more positivepotassium
 What also happens during the first half of the pacemaker period is an increase in the permeability for ___________ channelssodium
 The sodium channels that are open during the first half of the pacemaker period are called ___________funny sodium channels
 Opening of ___________ allows movement of positive ion from the outside of the cell toward the insidefunny sodium channels
 During the last half of the period of the pacemaker potential, there is an increase in the permeability for the membrane of ___________calcium
 Calcium ___________ the SA nodal cellsenters
 T channels stands for:Temporary
 The calcium channels that open during last half o the period of the pacemaker potential are called:T-channels
 ___________ potential is the phenomena that causes the SA node to spontaneously fire APPacemaker
 The ___________ has the highest spontaneous rate of AP firingSA node
 TF It is possible if the SA node is damaged or not working properly, then another cell excitatory part of the heart/tissue will take over and function as pacemakertrue
 If the SA node is not working properly, then ___________ will function as a pacemakerAV node
 ___________ has the next highest spontaneous rate of discharge after SA nodeAV node
 ___________ paces all of the other excitable cells in the heartSA node
 During ventricular AP, phase ___ is the period of the resting membrane potential4
 During ventricular AP, under normal circumstances, during phase ___ the membrane DOES come to a stable isoelectric potential4
 During phase 4 of ventricular AP, this period of time shows a relatively high permeability of _____________potassium
 During phase ___ of ventricular AP, potassium continuously leaks from interior to exterior4
 During phase 4 of ventricular AP, the type of potassium channel open is called:Leaky potassium channels
 During point ___ of ventricular AP, muscle fiber becomes stimulated0
 During phase ___ of ventricular AP, membrane fires the rapid upstroke of the AP0
 Increase in membrane potential during phase 0 of ventricular AP is caused by rapid increase in the permeability of muscle fibers for _____________sodium
 During phase 0 of ventricular AP, there is a FAST opening of _____________ channelssodium
 During ventricular AP, phase ___ is a brief period of repolarization1
 Phase 1 of ventricular AP is caused by a decrease in the permeability for _____________sodium
 During phase 1 of ventricular AP, there is an increase in permeability for _____________potassium
 During phase 1 of ventricular AP, potassium is leaving the cell, and brief repolarization brings membrane potential back to _____________negative
 What are the potassium channels called that are open during phase 1 of ventricular AP?temporary potassium channels
 What two things occur that cause a brief repolarization during phase 1 of ventricular AP?Decrease permeability of sodium and increased permeability for potassium
 During phase ___ of ventricular AP, the membrane becomes isoelectric for a long period of time2
 Phase ___ of ventricular AP is called the PLATEAU of the myocardial cell of the AP2
 During phase 2 of ventricular AP, there is an increase in permeability for _____________calcium
 The calcium channels that are open during phase 2 of ventricular AP are called:L- [long lasting] calcium channels
 L-calcium channels stand for:long lasting
 TF During phase 2 of ventricular AP, increase in the movement from ECL causes additional release of calcium from calcium stores in the SRtrue
 During phase 2 of ventricular AP, there is a decrease in the permeability of cell for _____________potassium
 During phase 2 of ventricular AP, combination of what keeps membrane potential at positive values for a long period of time? (2)Increase in permeability for calcium through L-channels and decrease in permeability for potassium
 During phase 2 of ventricular AP, there is a slow, long lasting influx of _____________calcium
 Phase ___ of ventricular AP is shown by a period of rapid repolarization3
 During phase 3 of ventricular AP, there is a decrease in permeability of _____________ through long lasting channelscalcium
 During phase ___ of ventricular AP, there is a decrease in permeability of calcium through long lasting channels3
 During phase 3 of ventricular AP, there is an increase in permeability for _____________ through ordinary channelspotassium
 During phase 3 of ventricular AP, as permeability for _____________ increases, the membrane can begin to fall and return to resting levelspotassium
 TF Cannot stimulate cardiac muscle cell and cause summation--- ABSOLUTE REFRACTORY PERIODtrue
 Almost entire duration of cardiac muscle AP, the membrane is _____________ refractory to further stimulationabsolutely
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