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NPBlec25 - Flashcards

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Class:NPB 101 - Systemic Physiology
Subject:Neurobiology,Physio & Behavior
University:University of California - Davis
Term:Fall 2010
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______ causes the firing of APs from the SA node at a set heart rate Pacemaker Potential
What happens during Phase 0 of a Ventricular Action Potential? spiked increase in mV increase in the permeability of sodium ions (Pna+) INC in Pna+
What happens during Phase 1 of a Ventricular Action Potential? small decrease in mV decrease in the permeability of sodium, increase in the permeability of potassium (by opening temporary K+ channels) DEC Pna+ INC Pk+
What happens during Phase 2 of a Ventricular Action Potential? it is a plateau increase in permeability of calcium, long lasting, movement through ion channels is slow, decrease in the permeability of potassium INC Pca2+ DEC Pk+
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What happens during Phase 3 of a Ventricular Action Potential? steady decline decrease in permeability of calcium, long lasting, increase in permeability of potassium, ordinary DEC Pca2+ INC Pk+
What happens during Phase 4 of a Ventricular Action Potential? level, resting membrane potential increase in permeability of potassium through leaky channels INC Pk+
________ has the highest natural rate of spontaneous action potential generation (of all self-excitatory cardiac tissues) Sino-Atrial Node (SA node)
what happens during phase 4 of the sinoatrial node action potential? first slope upwards slow leak of K+ channels in membrane decreases over time, slow entry of Na+ and Ca2+ into cell increases depolarization and membrane finally depolarizes itself once it reaches threshold slow DEC Pk+ slow INC Pna+ and PCa2+
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what is phase 4 of the SA node AP called? The pacemaker
what happens during phase 0 of the SA node AP? caused mainly by slow increase in PCa2+ although also an increase in P Na+
what is phase 0 of the SA node AP called? The Upstroke
what happens during phase 3 of the SA node AP? PCa2+ rapidly decreases, PNa+ slowly decreases, PK+ increases
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what is phase 3 of the SA node AP called? the repolarization
can APs in a cardiac cell summate? NO cannot re-stimulate cell for duration of AP absolute refractory period, cannot be tetanized (prolonged contraction caused by rapidly repeating APs)
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 ______ causes the firing of APs from the SA node at a set heart ratePacemaker Potential
 What happens during Phase 0 of a Ventricular Action Potential?spiked increase in mV
increase in the permeability of sodium ions (Pna+)

INC in Pna+
 What happens during Phase 1 of a Ventricular Action Potential?small decrease in mV
decrease in the permeability of sodium, increase in the permeability of potassium (by opening temporary K+ channels)

DEC Pna+
INC Pk+
 What happens during Phase 2 of a Ventricular Action Potential?it is a plateau
increase in permeability of calcium, long lasting, movement through ion channels is slow, decrease in the permeability of potassium

INC Pca2+
DEC Pk+
 What happens during Phase 3 of a Ventricular Action Potential?steady decline
decrease in permeability of calcium, long lasting, increase in permeability of potassium, ordinary

DEC Pca2+
INC Pk+
 What happens during Phase 4 of a Ventricular Action Potential?level, resting membrane potential
increase in permeability of potassium through leaky channels

INC Pk+
 ________ has the highest natural rate of spontaneous action potential generation (of all self-excitatory cardiac tissues)Sino-Atrial Node (SA node)
 what happens during phase 4 of the sinoatrial node action potential?first slope upwards
slow leak of K+ channels in membrane decreases over time, slow entry of Na+ and Ca2+ into cell increases depolarization and membrane finally depolarizes itself once it reaches threshold

slow DEC Pk+
slow INC Pna+ and PCa2+
 what is phase 4 of the SA node AP called?The pacemaker
 what happens during phase 0 of the SA node AP?caused mainly by slow increase in PCa2+ although also an increase in P Na+
 what is phase 0 of the SA node AP called?The Upstroke
 what happens during phase 3 of the SA node AP?PCa2+ rapidly decreases, PNa+ slowly decreases, PK+ increases
 what is phase 3 of the SA node AP called?the repolarization
 can APs in a cardiac cell summate? NO
cannot re-stimulate cell for duration of AP
absolute refractory period, cannot be tetanized (prolonged contraction caused by rapidly repeating APs)
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