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Exam 1 Drugs - Flashcards

Flashcard Deck Information

Class:PHM 350 - Intro Human Pharmacology
Subject:Pharmacology and Toxicology
University:Michigan State University
Term:Spring 2013
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doxazosin a1 antagonist 
glycopyrrolate  muscarinic antagonist 
metoprolol b1 antagonist 
phenylephrine a1 agonist 
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tamsulosin a1 antagonist 
albuterol b2 agonist 
dobutamine (a1), b1 agonist

*Catecholamine 
tiotropium muscarinic antagonist 
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activation of a2 adrenoreceptors decrease NE release 
methoxamine a1 agonist 
Endrophonium ChEase inhibitor 
Physostigmine ChEase inhibitor 
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Terazosin a1 antagonist 
benztropine muscarinic antagonist 
brimonidine a1 agonist 
Formoterol b2 agonist 
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Neostigmine ChEase inhibitor 
ritodrine b2 agonist 
tolterodine muscarinic antagonist 
acetylcholine muscarinic/nicotinic agonist 
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ipratropium muscarinic antagonist 
activation of b1 adrenoreceptors Increase:
HR,  CO, contractility, renin secretion (increase in BP and blood volume)
trimethaphan nicotinic antagonist 
non catecholamines absorb better in GI
Not substrates for MAO
longer half life
IV/injection/oral
emergency or every day uses
long/short term effects
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darifenacin muscarinic antagonist 
flavoaxate muscarinic antagonist 
cyclopentolate muscarinic antagonist 
terbutaline b2 agonist 
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carvedilol a1, b1, b2 antagonist 
pyridostigmine ChEase inhibitor 
Norepinephrine a1, a2, b1, (b2) agonist 

*Catecholamine 
dopamine a1, b1 agonist 

*Catecholamine 
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fesoterodine muscarinic antagonist 
Pilocarpine muscarinic agonist 
catecholamines less well absorbed in GI
substrate for MAO
shorter half life
IV
used in emergencies/short term effects
donepezil ChEase inhibitor 
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tropicamide muscarinic antagonists 
midodrine a1 agonist
nicotine nicotinic antagonist
atropine muscarinic antagonist 
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activation of b2 adrenoreceptors (6) vasodilation (heart and skeletal muscle)
bronchial relaxation
decrease intestinal motility
increase glycogenolysis (hyperglycemia)
increase insulin (hypoglycemia)
uterine relaxation 
atracurium nicotinic antagonist
clonidine a2 agonist
tacrine ChEase inhibitor 
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propranolol b1, b2 antagonist 
succinylcholine nicotinic antagonist 
atenolol b1 antagonist 
phentolamine a1, a2 antagonist 
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isoproternol b1, b2 agonist

*Catecholamine 
activation of a1 adrenoreceptors (5) vasoconstriction
mydiasis 
urine/fecal retention
hyperglycemia
uterine contraction 
gallamine nicotinic antagonist 
prazosin a2 antagonist 
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biperiden muscarinic antagonist 
trihexyphenidyl muscarinic antagonist 
echothiophate ChEase inhibitor 
Epinephrine a1, a2, b1, b2 agonist

**Catecholamine 
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Parathion ChEase inhibitor 
Labetalol a1, b1, b2 antagonist 
pindolol b1 antagonist 
bethanechol muscarinic agonist 
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Varenicline nicotinic agonist 
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 doxazosina1 antagonist 
 glycopyrrolate muscarinic antagonist 
 metoprololb1 antagonist 
 phenylephrinea1 agonist 
 tamsulosina1 antagonist 
 albuterolb2 agonist 
 dobutamine(a1), b1 agonist

*Catecholamine 
 tiotropiummuscarinic antagonist 
 activation of a2 adrenoreceptorsdecrease NE release 
 methoxaminea1 agonist 
 EndrophoniumChEase inhibitor 
 PhysostigmineChEase inhibitor 
 Terazosina1 antagonist 
 benztropinemuscarinic antagonist 
 brimonidinea1 agonist 
 Formoterolb2 agonist 
 NeostigmineChEase inhibitor 
 ritodrineb2 agonist 
 tolterodinemuscarinic antagonist 
 acetylcholinemuscarinic/nicotinic agonist 
 ipratropiummuscarinic antagonist 
 activation of b1 adrenoreceptorsIncrease:
HR,  CO, contractility, renin secretion (increase in BP and blood volume)
 trimethaphannicotinic antagonist 
 non catecholaminesabsorb better in GI
Not substrates for MAO
longer half life
IV/injection/oral
emergency or every day uses
long/short term effects
 darifenacinmuscarinic antagonist 
 flavoaxatemuscarinic antagonist 
 cyclopentolatemuscarinic antagonist 
 terbutalineb2 agonist 
 carvedilola1, b1, b2 antagonist 
 pyridostigmineChEase inhibitor 
 Norepinephrinea1, a2, b1, (b2) agonist 

*Catecholamine 
 dopaminea1, b1 agonist 

*Catecholamine 
 fesoterodinemuscarinic antagonist 
 Pilocarpinemuscarinic agonist 
 catecholaminesless well absorbed in GI
substrate for MAO
shorter half life
IV
used in emergencies/short term effects
 donepezilChEase inhibitor 
 tropicamidemuscarinic antagonists 
 midodrinea1 agonist
 nicotinenicotinic antagonist
 atropinemuscarinic antagonist 
 activation of b2 adrenoreceptors (6)vasodilation (heart and skeletal muscle)
bronchial relaxation
decrease intestinal motility
increase glycogenolysis (hyperglycemia)
increase insulin (hypoglycemia)
uterine relaxation 
 atracuriumnicotinic antagonist
 clonidinea2 agonist
 tacrineChEase inhibitor 
 propranololb1, b2 antagonist 
 succinylcholinenicotinic antagonist 
 atenololb1 antagonist 
 phentolaminea1, a2 antagonist 
 isoproternolb1, b2 agonist

*Catecholamine 
 activation of a1 adrenoreceptors (5)vasoconstriction
mydiasis 
urine/fecal retention
hyperglycemia
uterine contraction 
 gallaminenicotinic antagonist 
 prazosina2 antagonist 
 biperidenmuscarinic antagonist 
 trihexyphenidylmuscarinic antagonist 
 echothiophateChEase inhibitor 
 Epinephrinea1, a2, b1, b2 agonist

**Catecholamine 
 ParathionChEase inhibitor 
 Labetalola1, b1, b2 antagonist 
 pindololb1 antagonist 
 bethanecholmuscarinic agonist 
 Vareniclinenicotinic agonist 
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